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Fei D, Zhao K, Yuan H, et al. MicroRNA-187 exerts tumor-suppressing functions in osteosarcoma by targeting ZEB2. Am J Cancer Res. 2016;6(12):2859-2868
Fei, D., Zhao, K., Yuan, H., Xing, J., & Zhao, D. (2016). MicroRNA-187 exerts tumor-suppressing functions in osteosarcoma by targeting ZEB2. American journal of cancer research, 6(12), 2859-2868.
Fei, Dan, et al. "MicroRNA-187 exerts tumor-suppressing functions in osteosarcoma by targeting ZEB2." American journal of cancer research vol. 6,12 (2016): 2859-2868.
Fei D, Zhao K, Yuan H, Xing J, Zhao D. MicroRNA-187 exerts tumor-suppressing functions in osteosarcoma by targeting ZEB2. Am J Cancer Res. 2016 Dec 01;6(12):2859-2868. eCollection 2016. PMID: 28042505; PMCID: PMC5199759.
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Am J Cancer Res. 2016 Dec 01;6(12):2859-2868. eCollection 2016.

MicroRNA-187 exerts tumor-suppressing functions in osteosarcoma by targeting ZEB2.

American journal of cancer research

Dan Fei, Kunchi Zhao, Hongping Yuan, Jie Xing, Dongxu Zhao

Affiliations

  1. Department of Ultrasonographic, China-Japan Union Hospital of Jilin University Changchun 130033, Jilin, P. R. China.
  2. Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, Jilin, P. R. China.
  3. Department of Nephrology, The Fourth Hospital of Jilin University Changchun 130000, Jilin, P. R. China.

PMID: 28042505 PMCID: PMC5199759

Abstract

MicroRNA-187 (miR-187) has been reported to be involved in the occurrence and development of several types of cancers; however, a role for miR-187 in osteosarcoma (OS) has not yet been reported. Here, miR-187 was found to be significantly downregulated in OS cell lines and tissue samples, and decreased miR-187 expression was shown to be correlated closely with the TNM stage and lymph node metastasis. miR-187 overexpression suppressed OS cell proliferation, colony formation, migration, invasion, and epithelial-mesenchymal transition (EMT). Mechanically, zinc finger E-box binding homeobox 2 (ZEB2) was shown to serve as a direct target of miR-187 in OS cells and the overexpression of

Keywords: Osteosarcoma; ZEB2; miR-187; proliferation

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