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Mascarenhas DD, Ayadi AE, Wetzel M, et al. Effects of the nephrilin peptide on post-burn glycemic control, renal function, fat and lean body mass, and wound healing. Int J Burns Trauma. 2016;6(3):44-50
Mascarenhas, D. D., Ayadi, A. E., Wetzel, M., Prasai, A., Mifflin, R., Jay, J., Herndon, D. N., & Finnerty, C. C. (2016). Effects of the nephrilin peptide on post-burn glycemic control, renal function, fat and lean body mass, and wound healing. International journal of burns and trauma, 6(3), 44-50.
Mascarenhas, Desmond D, et al. "Effects of the nephrilin peptide on post-burn glycemic control, renal function, fat and lean body mass, and wound healing." International journal of burns and trauma vol. 6,3 (2016): 44-50.
Mascarenhas DD, Ayadi AE, Wetzel M, Prasai A, Mifflin R, Jay J, Herndon DN, Finnerty CC. Effects of the nephrilin peptide on post-burn glycemic control, renal function, fat and lean body mass, and wound healing. Int J Burns Trauma. 2016 Nov 30;6(3):44-50. eCollection 2016. PMID: 28078180; PMCID: PMC5218868.
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Int J Burns Trauma. 2016 Nov 30;6(3):44-50. eCollection 2016.

Effects of the nephrilin peptide on post-burn glycemic control, renal function, fat and lean body mass, and wound healing.

International journal of burns and trauma

Desmond D Mascarenhas, Amina El Ayadi, Michael Wetzel, Anesh Prasai, Randy Mifflin, Jayson Jay, David N Herndon, Celeste C Finnerty

Affiliations

  1. Mayflower Organization for Research & EducationSunnyvale, CA 94085, USA; Transporin, Inc.Sunnyvale, CA 94085, USA.
  2. Department of Surgery, The University of Texas Medical BranchUSA; Shriners Hospitals for Children - GalvestonGalveston, TX 77550, USA.
  3. Shriners Hospitals for Children - GalvestonGalveston, TX 77550, USA; Cell Biology Graduate Program, The University of Texas Medical BranchGalveston, TX 77555, USA.
  4. Shriners Hospitals for Children - GalvestonGalveston, TX 77550, USA; The Institute for Translational Sciences and The Sealy Center for Molecular Medicine, The University of Texas Medical BranchGalveston, TX 77550, USA.
  5. Department of Surgery, The University of Texas Medical BranchUSA; Shriners Hospitals for Children - GalvestonGalveston, TX 77550, USA; The Institute for Translational Sciences and The Sealy Center for Molecular Medicine, The University of Texas Medical BranchGalveston, TX 77550, USA.

PMID: 28078180 PMCID: PMC5218868

Abstract

The mechanisms underlying the effects of severe burn trauma are not well understood. We previously demonstrated the ability of nephrilin peptide (an iron-binding peptide believed to enter cells through iron-uptake pathways) to suppress aspects of the neuroinflammatory response in a rat scald model, as well as sepsis mortality in a mouse model. This study explores the effect of nephrilin on other clinically relevant outcomes in the rat scald model. In a rat scald model, animals were treated with nephrilin either in week 1 or week 2 post-burn. Measurements were made of serum glucose and creatinine as well as wound area by planimetry and body composition by DEXA. Given the potential role of iron, results were analyzed both for the entire cohort of animals and for the normoferremic (>100 ug/dL serum iron) subset of animals. Nephrilin improved body composition, wound healing, kidney function, and glycemic control. The first two effects were significant in normoferremic but not in hypoferremic animals suggesting an effect of iron status on burn injury outcomes. Nephrilin treatment modulates a number of relevant variables in the rat scald model.

Keywords: Nephrilin; burn injury; eGFR; glycemic control; iron; lean body mass; wound healing

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