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Gad A, Kydd J, Piel B, et al. Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy. Int J Nanomed Nanosurg. 2016;2(3)doi: 10.16966/2470-3206.116.
Gad, A., Kydd, J., Piel, B., & Rai, P. (2016). Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy. International journal of nanomedicine and nanosurgery, 2(3), . https://doi.org/10.16966/2470-3206.116
Gad, Aniket, et al. "Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy." International journal of nanomedicine and nanosurgery vol. 2,3 (2016). doi: https://doi.org/10.16966/2470-3206.116
Gad A, Kydd J, Piel B, Rai P. Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy. Int J Nanomed Nanosurg. 2016 Sep;2(3). doi: 10.16966/2470-3206.116. Epub 2016 Jul 04. PMID: 28042613; PMCID: PMC5193385.
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Int J Nanomed Nanosurg. 2016 Sep;2(3). doi: 10.16966/2470-3206.116. Epub 2016 Jul 04.

Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy.

International journal of nanomedicine and nanosurgery

Aniket Gad, Janel Kydd, Brandon Piel, Prakash Rai

Affiliations

  1. Biomedical Engineering and Biotechnology Program, University of Massachusetts, Lowell, USA.
  2. Department of Chemical Engineering, University of Massachusetts, Lowell-1 University Ave, USA.
  3. Biomedical Engineering and Biotechnology Program, University of Massachusetts, Lowell, USA; Department of Chemical Engineering, University of Massachusetts, Lowell-1 University Ave, USA.

PMID: 28042613 PMCID: PMC5193385 DOI: 10.16966/2470-3206.116

Abstract

Cancer forms exhibiting poor prognosis have been extensively researched for therapeutic solutions. One of the conventional modes of treatment, chemotherapy shows inadequacy in its methodology due to imminent side-effects and acquired drug-resistance by cancer cells. However, advancements in nanotechnology have opened new frontiers to significantly alleviate collateral damage caused by current treatments via innovative delivery techniques, eliminating pitfalls encountered in conventional treatments. Properties like reduced drug-clearance and increased dose efficacy by the enhanced permeability and retention effect deem nanoparticles suitable for this application. Optimization of size, surface charge and surface modifications have provided nanoparticles with stealth properties capable of evading immune responses, thus deeming them as excellent carriers of chemotherapeutic agents. Biocompatible and biodegradable forms of polymers enhance the bioavailability of chemotherapeutic agents, and permit a sustained and time-dependent release of drugs which is a characteristic of their composition, thereby providing a controlled therapeutic approach. Studies conducted

Keywords: Biocompatibility; Biodegradability; Biopolymers; Controlled release; Drug delivery; Enhanced permeability and retention; Multi-drug resistance; Nanomedicine; Oncology; Receptor mediated endocytosis

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