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Srichomkwun P, Scherberg NH, Jakšić J, et al. Diagnostic Dilemma in Discordant Thyroid Function Tests Due to Thyroid Hormone Autoantibodies. AACE Clin Case Rep. 2017;3(1):e22-e25doi: 10.4158/EP151142.CR.
Srichomkwun, P., Scherberg, N. H., Jakšić, J., & Refetoff, S. (2017). Diagnostic Dilemma in Discordant Thyroid Function Tests Due to Thyroid Hormone Autoantibodies. AACE clinical case reports, 3(1), e22-e25. https://doi.org/10.4158/EP151142.CR
Srichomkwun, Panudda, et al. "Diagnostic Dilemma in Discordant Thyroid Function Tests Due to Thyroid Hormone Autoantibodies." AACE clinical case reports vol. 3,1 (2017): e22-e25. doi: https://doi.org/10.4158/EP151142.CR
Srichomkwun P, Scherberg NH, Jakšić J, Refetoff S. Diagnostic Dilemma in Discordant Thyroid Function Tests Due to Thyroid Hormone Autoantibodies. AACE Clin Case Rep. 2017;3(1):e22-e25. doi: 10.4158/EP151142.CR. PMID: 28078322; PMCID: PMC5222615.
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AACE Clin Case Rep. 2017;3(1):e22-e25. doi: 10.4158/EP151142.CR.

Diagnostic Dilemma in Discordant Thyroid Function Tests Due to Thyroid Hormone Autoantibodies.

AACE clinical case reports

Panudda Srichomkwun, Neal H Scherberg, Jasminka Jakšić, Samuel Refetoff

Affiliations

  1. Department of Medicine, The University of Chicago, Chicago, Illinois.
  2. Department of Pediatrics, General Hospital, Sibenik, Croatia.
  3. Department of Medicine, The University of Chicago, Chicago, Illinois; Department of Pediatrics and the Committee on Genetics, The University of Chicago, Chicago, Illinois.

PMID: 28078322 PMCID: PMC5222615 DOI: 10.4158/EP151142.CR

Abstract

OBJECTIVE: Assay interference could be the cause of abnormal thyroid function tests. Early recognition prevents inappropriate patient management. The objective of this report is to present a case with discordant thyroid function tests in different thyroid assay platforms due to thyroid autoantibodies.

METHODS: We present a case her family, laboratory data and methods that investigate immunoassay interference.

RESULTS: A 21-year-old woman with autoimmune thyroid disease was treated for hypothyroidism with levothyroxine and noted to have elevated total and free thyroxine, free triiodothyronine but normal thyroid-stimulating hormone. Repeat thyroid function tests using different platforms revealed discrepant results. Further investigation showed that the patient had positive thyroid hormone autoantibodies (THAAbs).

CONCLUSION: We demonstrates abnormal thyroid function tests caused by THAAbs. The latter were the cause of interference with assays resulting in discrepant test results inconsistent with the clinical presentation. Early recognition would prevent inappropriate patient management.

Keywords: euthyroid hyperthyroxinemia; thyroid function test; thyroid hormone autoantibodies

References

  1. Thyroid Res. 2012 Oct 29;5(1):11 - PubMed
  2. Biochim Biophys Acta. 2013 Jul;1830(7):3987-4003 - PubMed
  3. Best Pract Res Clin Endocrinol Metab. 2013 Dec;27(6):745-62 - PubMed
  4. J Clin Endocrinol Metab. 2014 Mar;99(3):768-70 - PubMed
  5. Clin Chem. 2005 Jan;51(1):25-6 - PubMed
  6. Ann Intern Med. 1985 Oct;103(4):579-89 - PubMed
  7. Clin Chem. 1998 Mar;44(3):440-54 - PubMed
  8. J Clin Endocrinol Metab. 2010 Jul;95(7):3189-93 - PubMed
  9. Clin Chem. 2008 May;54(5):927-8 - PubMed
  10. Clin Endocrinol (Oxf). 2006 Mar;64(3):234-44 - PubMed

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