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Duclos CM, Champagne A, Carrier JC, et al. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov. 2017;3:16100doi: 10.1038/cddiscovery.2016.100.
Duclos, C. M., Champagne, A., Carrier, J. C., Saucier, C., Lavoie, C. L., & Denault, J. B. (2017). Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell death discovery, 316100. https://doi.org/10.1038/cddiscovery.2016.100
Duclos, Catherine M, et al. "Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling." Cell death discovery vol. 3 (2017): 16100. doi: https://doi.org/10.1038/cddiscovery.2016.100
Duclos CM, Champagne A, Carrier JC, Saucier C, Lavoie CL, Denault JB. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov. 2017 Jan 23;3:16100. doi: 10.1038/cddiscovery.2016.100. eCollection 2017. PMID: 28179995; PMCID: PMC5253419.
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Cell Death Discov. 2017 Jan 23;3:16100. doi: 10.1038/cddiscovery.2016.100. eCollection 2017.

Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling.

Cell death discovery

Catherine M Duclos, Audrey Champagne, Julie C Carrier, Caroline Saucier, Christine L Lavoie, Jean-Bernard Denault

Affiliations

  1. Department of Pharmacology-Physiology and Institut de Pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Université de Sherbrooke , 3001, 12th Avenue North, Sherbrooke, QC, Canada J1H 5N4.
  2. Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke , 3001, 12th Avenue North, Sherbrooke, QC, Canada J1H 5N4.

PMID: 28179995 PMCID: PMC5253419 DOI: 10.1038/cddiscovery.2016.100

Abstract

The unfolding of apoptosis involves the cleavage of hundreds of proteins by the caspase family of cysteinyl peptidases. Among those substrates are proteins involved in intracellular vesicle trafficking with a net outcome of shutting down the crucial processes governing protein transport to organelles and to the plasma membrane. However, because of the intertwining of receptor trafficking and signaling, cleavage of specific proteins may lead to unintended consequences. Here we show that in apoptosis, sorting nexin 1 and 2 (SNX1 and SNX2), two proteins involved in endosomal sorting, are cleaved by initiator caspases and also by executioner caspase-6 in the case of SNX2. Moreover, SNX1 is cleaved at multiple sites, including following glutamate residues. Cleavage of SNX2 results in a loss of association with the endosome-to-

References

  1. Mol Biol Cell. 2004 May;15(5):2143-55 - PubMed
  2. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15173-7 - PubMed
  3. Cell Death Differ. 2001 May;8(5):443-50 - PubMed
  4. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G677-86 - PubMed
  5. Traffic. 2008 Mar;9(3):366-79 - PubMed
  6. J Cell Biol. 2004 Apr;165(1):111-22 - PubMed
  7. Mol Biol Cell. 2002 Mar;13(3):978-88 - PubMed
  8. Traffic. 2010 Apr;11(4):508-19 - PubMed
  9. J Biol Chem. 2014 Oct 17;289(42):29180-94 - PubMed
  10. J Biol Chem. 2002 Dec 13;277(50):48730-6 - PubMed
  11. Int J Oncol. 2014 Feb;44(2):412-26 - PubMed
  12. Cell Death Differ. 2016 Oct;23 (10 ):1717-26 - PubMed
  13. Biochem J. 2000 Sep 1;350 Pt 2:563-8 - PubMed
  14. J Cell Sci. 2008 Jun 15;121(Pt 12):2027-36 - PubMed
  15. J Cell Sci. 1998 May;111 ( Pt 10):1441-51 - PubMed
  16. J Cell Biol. 1999 Jan 25;144(2):281-92 - PubMed
  17. Nature. 2012 Jul 18;487(7407):330-7 - PubMed
  18. Mol Cell. 2003 Feb;11(2):529-41 - PubMed
  19. Cell Death Dis. 2013 Oct 17;4:e871 - PubMed
  20. Mol Biol Cell. 2002 Jun;13(6):1965-76 - PubMed
  21. BMC Cancer. 2014 Apr 04;14:240 - PubMed
  22. Mol Cell Proteomics. 2013 Mar;12(3):813-24 - PubMed
  23. Cell. 2008 Aug 22;134(4):679-91 - PubMed
  24. Cell Death Differ. 2003 Jan;10(1):76-100 - PubMed
  25. EMBO J. 2012 Nov 28;31(23):4466-80 - PubMed
  26. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8395-400 - PubMed
  27. Cell. 2009 Sep 4;138(5):838-54 - PubMed
  28. Annu Rev Pharmacol Toxicol. 2015 ;55:553-72 - PubMed
  29. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D270-2 - PubMed
  30. Nat Rev Neurosci. 2015 Mar;16(3):126-32 - PubMed
  31. Cell Death Differ. 2002 Oct;9(10):1046-56 - PubMed
  32. Cell. 1996 Oct 18;87(2):171 - PubMed
  33. J Biol Chem. 1997 Jul 18;272(29):17907-11 - PubMed
  34. Tumour Biol. 2016 May;37(5):6619-25 - PubMed
  35. Biochem J. 2004 Dec 1;384(Pt 2):201-32 - PubMed
  36. Mol Cell Proteomics. 2013 May;12 (5):1436-50 - PubMed
  37. Cell Death Differ. 2013 Jan;20(1):86-96 - PubMed
  38. Chem Rev. 2002 Dec;102(12):4489-500 - PubMed
  39. J Biol Chem. 1998 Dec 11;273(50):33533-9 - PubMed
  40. Cell Death Differ. 2007 Apr;14(4):752-64 - PubMed
  41. Biochem Biophys Res Commun. 2007 Jun 29;358(2):566-70 - PubMed
  42. Mol Cell Biol. 2007 Feb;27(3):1112-24 - PubMed
  43. EMBO J. 1997 Oct 15;16(20):6182-91 - PubMed
  44. Mol Biol Cell. 2006 Mar;17(3):1228-38 - PubMed
  45. J Cell Sci. 2004 Mar 1;117(Pt 7):1139-50 - PubMed
  46. J Biol Chem. 2013 Jan 4;288(1):152-63 - PubMed
  47. PLoS One. 2010 Dec 23;5(12):e15742 - PubMed
  48. EMBO J. 2002 Apr 15;21(8):1967-77 - PubMed
  49. FEBS Lett. 2004 Jan 2;556(1-3):276-80 - PubMed
  50. Mol Cell Biol. 2004 Dec;24(23):10328-39 - PubMed
  51. J Biol Chem. 1997 Oct 10;272(41):25719-23 - PubMed
  52. J Biol Chem. 1999 Dec 31;274(53):37583-90 - PubMed
  53. EMBO J. 2003 Dec 15;22(24):6537-49 - PubMed
  54. Cancer Sci. 2013 May;104(5):573-83 - PubMed
  55. Mol Cell Biol. 1998 Dec;18(12):7278-87 - PubMed
  56. J Biol Chem. 2002 Mar 8;277(10):8226-34 - PubMed
  57. Cell. 1995 Jun 2;81(5):801-9 - PubMed
  58. J Cell Biol. 2004 Apr;165(1):123-33 - PubMed
  59. Mol Biol Cell. 2000 Dec;11(12):4105-16 - PubMed
  60. J Biol Chem. 1987 Jul 25;262(21):10035-8 - PubMed
  61. Biochem J. 2012 Jan 1;441(1):39-59 - PubMed
  62. Science. 1996 May 17;272(5264):1008-10 - PubMed
  63. Biochem Biophys Res Commun. 2008 Mar 14;367(3):573-7 - PubMed
  64. Methods Enzymol. 2000;322:91-100 - PubMed
  65. J Cell Sci. 2007 Jan 1;120(Pt 1):45-54 - PubMed
  66. J Proteome Res. 2016 Sep 2;15(9):2924-34 - PubMed
  67. Curr Biol. 2004 Oct 26;14(20):1791-800 - PubMed
  68. Methods Mol Biol. 2014;1133:3-39 - PubMed
  69. Dev Cell. 2009 Jul;17 (1):110-22 - PubMed
  70. Clin Cancer Res. 2006 Dec 1;12(23):6952-9 - PubMed

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