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Wang Y, Zhao XY, Xu LP, et al. Lower incidence of acute GVHD is associated with the rapid recovery of CD4. Oncoimmunology. 2016;5(12):e1242546doi: 10.1080/2162402X.2016.1242546.
Wang, Y., Zhao, X. Y., Xu, L. P., Zhang, X. H., Han, W., Chen, H., Wang, F. R., Mo, X. D., Zhang, Y. Y., Zhao, X. S., Y, K., Liua, K. Y., Huang, X. J., Yu, X. Z., & Chang, Y. J. (2016). Lower incidence of acute GVHD is associated with the rapid recovery of CD4. Oncoimmunology, 5(12), e1242546. https://doi.org/10.1080/2162402X.2016.1242546
Wang, Yu, et al. "Lower incidence of acute GVHD is associated with the rapid recovery of CD4." Oncoimmunology vol. 5,12 (2016): e1242546. doi: https://doi.org/10.1080/2162402X.2016.1242546
Wang Y, Zhao XY, Xu LP, Zhang XH, Han W, Chen H, Wang FR, Mo XD, Zhang YY, Zhao XS, Y K, Liua KY, Huang XJ, Yu XZ, Chang YJ. Lower incidence of acute GVHD is associated with the rapid recovery of CD4. Oncoimmunology. 2016 Oct 14;5(12):e1242546. doi: 10.1080/2162402X.2016.1242546. eCollection 2016. PMID: 28180031; PMCID: PMC5215191.
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Oncoimmunology. 2016 Oct 14;5(12):e1242546. doi: 10.1080/2162402X.2016.1242546. eCollection 2016.

Lower incidence of acute GVHD is associated with the rapid recovery of CD4.

Oncoimmunology

Yu Wang, Xiang-Yu Zhao, Lan-Ping Xu, Xiao-Hui Zhang, Wei Han, Huan Chen, Feng-Rong Wang, Xiao-Dong Mo, Yuan-Yuan Zhang, Xiao-Su Zhao, Kong Y, Kai-Yan Liua, Xiao-Jun Huang, Xue-Zhong Yu, Ying-Jun Chang

Affiliations

  1. Peking University People's Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing, P.R. China.
  2. Peking University People's Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, P.R. China; Peking-Tsinghua Center for Life Sciences, Beijing, P.R. China.
  3. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA; Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.

PMID: 28180031 PMCID: PMC5215191 DOI: 10.1080/2162402X.2016.1242546

Abstract

To investigate the effects of non-inherited maternal antigen (NIMA) on clinical outcomes and immune recovery, especially of regulatory T cells (Tregs), in patients who underwent unmanipulated haploidentical transplantation. A retrospective cohort (n = 57) and a prospective cohort (n = 88) were included. All patients received haploidentical allografts from sibling donors. Reconstitution of immune subsets, including Tregs, was determined using multicolor flow cytometry. In the retrospective cohort, the cumulative incidence of grades II-IV acute GVHD in patients with NIMA-mismatched donors was significantly lower than that of cases with NIPA-mismatched donors (14.8% vs. 43.30%,

Keywords: Graft-versus-host disease; haploidentical stem cell transplantation; immune reconstitution; non-inherited maternal antigen; regulatory T cells

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