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Mohan A, Arora S, Uniyal A, et al. Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease. Lung India. 2017;34(1):3-8doi: 10.4103/0970-2113.197101.
Mohan, A., Arora, S., Uniyal, A., Poulose, R., Luthra, K., Pandey, R. M., & Guleria, R. (2017). Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease. Lung India : official organ of Indian Chest Society, 34(1), 3-8. https://doi.org/10.4103/0970-2113.197101
Mohan, Anant, et al. "Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease." Lung India : official organ of Indian Chest Society vol. 34,1 (2017): 3-8. doi: https://doi.org/10.4103/0970-2113.197101
Mohan A, Arora S, Uniyal A, Poulose R, Luthra K, Pandey RM, Guleria R. Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease. Lung India. 2017 Jan-Feb;34(1):3-8. doi: 10.4103/0970-2113.197101. PMID: 28144052; PMCID: PMC5234195.
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Lung India. 2017 Jan-Feb;34(1):3-8. doi: 10.4103/0970-2113.197101.

Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease.

Lung India : official organ of Indian Chest Society

Anant Mohan, Sneh Arora, Arvind Uniyal, Rosemary Poulose, Kalpana Luthra, R M Pandey, Randeep Guleria

Affiliations

  1. Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
  2. Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
  3. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

PMID: 28144052 PMCID: PMC5234195 DOI: 10.4103/0970-2113.197101

Abstract

BACKGROUND: Inflammatory and nutritional biomarkers have an important bearing on outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but the temporal profile of these compounds during an acute episode is unclear.

PATIENTS AND METHODS: Plasma leptin, prealbumin, and tumor necrosis factor-alpha (TNF-α) were estimated at baseline and before hospital discharge in patients with AECOPD.

RESULTS: A total of 82 patients were evaluated (66 males; mean (standard deviation) age, 61.6 (10.1) years. Of these, 74 subjects (90.2%) were current or former smokers, with median (range) pack-years of 15 (0-96), duration of COPD of 8 years (range, 2-25 years) and duration of current symptoms being 5 days (range, 1-30 days). Majority (41.5%) had type I (severe) exacerbation. During the current episode, 46 patients (58.9%) required mechanical ventilation for a median of 6 days (range, 1-34). The median duration of hospital stay was 13 days, (range, 1-110). At discharge, significant reduction was observed in dyspnea, total leukocyte count, erythrocyte sedimentation rate (ESR), partial pressure of carbon dioxide, hemoglobin, urea, creatinine, potassium, aspartate transferase, and TNF-α levels compared to baseline, whereas arterial pH, PO

CONCLUSION: Plasma levels of novel inflammatory and nutritional biomarkers, i.e., leptin, TNF-α, and prealbumin are altered in AECOPD episodes and lag behind other parameters during recovery. These biomarkers are not reliable predictors of clinical outcomes in these patients.

Keywords: Chronic obstructive pulmonary disease; inflammatory; leptin; prealbumin; tumor necrosis factor-alpha

Conflict of interest statement

There are no conflicts of interest.

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