Display options
Share it on

Front Microbiol. 2017 Jan 17;7:2151. doi: 10.3389/fmicb.2016.02151. eCollection 2016.

Human Catestatin Alters Gut Microbiota Composition in Mice.

Frontiers in microbiology

Mohammad F Rabbi, Peris M Munyaka, Nour Eissa, Marie-Hélène Metz-Boutigue, Ehsan Khafipour, Jean Eric Ghia

Affiliations

  1. Department of Immunology, University of Manitoba Winnipeg, MB, Canada.
  2. Department of Immunology, University of ManitobaWinnipeg, MB, Canada; Department of Animal Sciences, University of ManitobaWinnipeg, MB, Canada.
  3. Biomaterials and Tissue Engineering, Institut National de la Santé et de la Recherche Médicale Strasbourg, France.
  4. Department of Animal Sciences, University of ManitobaWinnipeg, MB, Canada; Department of Medical Microbiology, University of ManitobaWinnipeg, MB, Canada; The Children's Hospital Research Institute of ManitobaWinnipeg, MB, Canada.
  5. Department of Immunology, University of ManitobaWinnipeg, MB, Canada; The Children's Hospital Research Institute of ManitobaWinnipeg, MB, Canada; Section of Gastroenterology, Department of Internal Medicine, University of ManitobaWinnipeg, MB, Canada; Inflammatory Bowel Disease Clinical and Research Centre, University of ManitobaWinnipeg, MB, Canada.

PMID: 28144234 PMCID: PMC5239785 DOI: 10.3389/fmicb.2016.02151

Abstract

The mammalian intestinal tract is heavily colonized with a dense, complex, and diversified microbial populations. In healthy individuals, an array of epithelial antimicrobial agents is secreted in the gut to aid intestinal homeostasis. Enterochromaffin cells (EC) in the intestinal epithelium are a major source of chromogranin A (CgA), which is a pro-hormone and can be cleaved into many bioactive peptides that include catestatin (CST). This study was carried out to evaluate the possible impact of CST on gut microbiota

Keywords: antimicrobial peptides; catestatin (CST); chromogranin A (CgA); gut microbiota; intestinal homeostasis; microbial dysbiosis

References

  1. Inflamm Bowel Dis. 2007 Jun;13(6):675-83 - PubMed
  2. Appl Environ Microbiol. 2006 Jul;72(7):5069-72 - PubMed
  3. Front Microbiol. 2016 Mar 31;7:426 - PubMed
  4. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9 - PubMed
  5. Clin Exp Immunol. 2010 Jul 1;161(1):19-27 - PubMed
  6. J Dig Dis. 2013 Oct;14(10):513-7 - PubMed
  7. PLoS One. 2010 Mar 10;5(3):e9490 - PubMed
  8. Nat Immunol. 2003 Mar;4(3):269-73 - PubMed
  9. Nat Rev Immunol. 2006 Nov;6(11):849-58 - PubMed
  10. ILAR J. 2002;43 Suppl:S99-S104 - PubMed
  11. Bioinformatics. 2011 Aug 15;27(16):2194-200 - PubMed
  12. ISME J. 2012 Aug;6(8):1621-4 - PubMed
  13. PLoS One. 2011;6(12):e28991 - PubMed
  14. Respir Res. 2000;1(3):141-50 - PubMed
  15. Hum Genet. 2003 May;112(5-6):581-92 - PubMed
  16. Trends Microbiol. 2008 Mar;16(3):107-14 - PubMed
  17. Nature. 1987 Jan 22-28;325(6102):301 - PubMed
  18. Curr Med Chem. 2012;19(24):4115-23 - PubMed
  19. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20858-63 - PubMed
  20. Microb Ecol Health Dis. 2015 Feb 02;26:26191 - PubMed
  21. EMBO Mol Med. 2013 Oct;5(10):1465-83 - PubMed
  22. Appl Environ Microbiol. 2007 Aug;73(16):5261-7 - PubMed
  23. PLoS One. 2012;7(12):e51897 - PubMed
  24. BMC Bioinformatics. 2012 Feb 14;13:31 - PubMed
  25. Appl Environ Microbiol. 2009 Nov;75(22):7115-24 - PubMed
  26. Science. 2016 Apr 29;352(6285):565-9 - PubMed
  27. Biotechnol Genet Eng Rev. 2010;26:335-52 - PubMed
  28. Brain Res. 1999 Nov 27;848(1-2):45-62 - PubMed
  29. J Physiol. 2012 Feb 1;590(3):441-6 - PubMed
  30. J Invest Dermatol. 2001 Jul;117(1):91-7 - PubMed
  31. Clin Microbiol Rev. 2007 Oct;20(4):593-621 - PubMed
  32. Bioinformatics. 2010 Jan 15;26(2):266-7 - PubMed
  33. Nat Methods. 2010 May;7(5):335-6 - PubMed
  34. J Basic Microbiol. 2016 Sep;56(9):986-98 - PubMed
  35. Regul Pept. 2010 Jun 8;162(1-3):33-43 - PubMed
  36. J Clin Invest. 2005 Jul;115(7):1942-52 - PubMed
  37. J Clin Gastroenterol. 2012 Jan;46(1):16-24 - PubMed
  38. Histochemistry. 1991;96(6):531-8 - PubMed
  39. Bioinformatics. 2010 Mar 15;26(6):715-21 - PubMed
  40. Lab Invest. 1993 Aug;69(2):238-49 - PubMed
  41. Annu Rev Microbiol. 1984;38:293-313 - PubMed
  42. Appl Environ Microbiol. 2005 Dec;71(12):8228-35 - PubMed
  43. Biochem Pharmacol. 2014 Jun 1;89(3):386-98 - PubMed
  44. Nat Biotechnol. 2013 Sep;31(9):814-21 - PubMed
  45. Appl Environ Microbiol. 2002 Jul;68(7):3401-7 - PubMed
  46. J Histochem Cytochem. 2001 Jan;49(1):9-18 - PubMed
  47. Cell Host Microbe. 2008 Jun 12;3(6):417-27 - PubMed
  48. Cell Mol Life Sci. 2005 Feb;62(3):377-85 - PubMed
  49. Bioinformatics. 2010 Oct 1;26(19):2460-1 - PubMed
  50. Ital J Pediatr. 2014 Mar 31;40:32 - PubMed
  51. J Histochem Cytochem. 2001 Apr;49(4):483-90 - PubMed
  52. Infect Immun. 1993 Jul;61(7):2978-84 - PubMed
  53. Inflamm Bowel Dis. 2011 Apr;17(4):917-26 - PubMed
  54. Nat Immunol. 2010 Jan;11(1):76-83 - PubMed
  55. J Histochem Cytochem. 2002 Nov;50(11):1487-92 - PubMed
  56. Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33 - PubMed
  57. Science. 2006 May 5;312(5774):700-1 - PubMed
  58. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):497-505 - PubMed
  59. Annu Rev Immunol. 2010;28:573-621 - PubMed
  60. J Clin Invest. 1997 Sep 15;100(6):1623-33 - PubMed

Publication Types