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Cisneros E, Estefanía E, Vilches C. Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f). Front Immunol. 2017;7:698doi: 10.3389/fimmu.2016.00698.
Cisneros, E., Estefanía, E., & Vilches, C. (2016). Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f). Frontiers in immunology, 7698. https://doi.org/10.3389/fimmu.2016.00698
Cisneros, Elisa, et al. "Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f)." Frontiers in immunology vol. 7 (2016): 698. doi: https://doi.org/10.3389/fimmu.2016.00698
Cisneros E, Estefanía E, Vilches C. Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f). Front Immunol. 2017 Jan 17;7:698. doi: 10.3389/fimmu.2016.00698. eCollection 2016. PMID: 28144240; PMCID: PMC5239777.
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Front Immunol. 2017 Jan 17;7:698. doi: 10.3389/fimmu.2016.00698. eCollection 2016.

Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f).

Frontiers in immunology

Elisa Cisneros, Ernesto Estefanía, Carlos Vilches

Affiliations

  1. Immunogenetics and Histocompatibility, Instituto de Investigación Sanitaria Puerta de Hierro , Madrid , Spain.

PMID: 28144240 PMCID: PMC5239777 DOI: 10.3389/fimmu.2016.00698

Abstract

KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. Unlike KIR2DL1-3, recognizing HLA-C allotypes through Ig-like domains of the D1-D2 type, KIR2DL5 shares a D0-D2 configuration with KIR2DL4, and its ligands have not been identified. KIR2DL5 is encoded by two paralogous genes displaying copy number variation and allelic polymorphism-

Keywords: KIR; NK-cell receptors; allelic polymorphism; natural killer cells; repertoire development

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