Display options
Cite
Pessel F, Augé J, Billault I, et al. The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography. Beilstein J Org Chem. 2016;12:2351-2357doi: 10.3762/bjoc.12.228.
Pessel, F., Augé, J., Billault, I., & Scherrmann, M. C. (2016). The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography. Beilstein journal of organic chemistry, 122351-2357. https://doi.org/10.3762/bjoc.12.228
Pessel, Freddy, et al. "The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography." Beilstein journal of organic chemistry vol. 12 (2016): 2351-2357. doi: https://doi.org/10.3762/bjoc.12.228
Pessel F, Augé J, Billault I, Scherrmann MC. The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography. Beilstein J Org Chem. 2016 Nov 08;12:2351-2357. doi: 10.3762/bjoc.12.228. eCollection 2016. PMID: 28144302; PMCID: PMC5238533.
Copy Download .nbib Format: NLM
Share it on

Beilstein J Org Chem. 2016 Nov 08;12:2351-2357. doi: 10.3762/bjoc.12.228. eCollection 2016.

The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography.

Beilstein journal of organic chemistry

Freddy Pessel, Jacques Augé, Isabelle Billault, Marie-Christine Scherrmann

Affiliations

  1. Université Paris Sud, ICMMO, UMR CNRS 8182, Bâtiment 420, 91405 Orsay Cedex, France.
  2. Université de Cergy-Pontoise, LCB, EA 4505, 5 mail Gay-Lussac, Neuville sur Oise, 95031 Cergy-Pontoise, France.

PMID: 28144302 PMCID: PMC5238533 DOI: 10.3762/bjoc.12.228

Abstract

Purification by flash chromatography strongly impacts the greenness of a process. Unfortunately, due to the lack of the relevant literature data, very often this impact cannot be assessed thus preventing the comparison of the environmental factors affecting the syntheses. We developed a simple mathematical approach to evaluate the minimum mass intensity of flash chromatography from the retention factor values determined by thin-layer chromatography.

Keywords: environmental factor; flash chromatography; green metrics; mass intensity; purification

References

  1. Chemistry. 2002 Aug 16;8(16):3580-5 - PubMed
  2. J Chromatogr A. 2008 Nov 21;1211(1-2):49-54 - PubMed
  3. Mol Divers. 2009 May;13(2):247-52 - PubMed
  4. J Chromatogr A. 2012 Aug 10;1250:264-73 - PubMed

Publication Types