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Greiner AM, Sales A, Chen H, et al. Nano- and microstructured materials for in vitro studies of the physiology of vascular cells. Beilstein J Nanotechnol. 2016;7:1620-1641doi: 10.3762/bjnano.7.155.
Greiner, A. M., Sales, A., Chen, H., Biela, S. A., Kaufmann, D., & Kemkemer, R. (2016). Nano- and microstructured materials for in vitro studies of the physiology of vascular cells. Beilstein journal of nanotechnology, 71620-1641. https://doi.org/10.3762/bjnano.7.155
Greiner, Alexandra M, et al. "Nano- and microstructured materials for in vitro studies of the physiology of vascular cells." Beilstein journal of nanotechnology vol. 7 (2016): 1620-1641. doi: https://doi.org/10.3762/bjnano.7.155
Greiner AM, Sales A, Chen H, Biela SA, Kaufmann D, Kemkemer R. Nano- and microstructured materials for in vitro studies of the physiology of vascular cells. Beilstein J Nanotechnol. 2016 Nov 08;7:1620-1641. doi: 10.3762/bjnano.7.155. eCollection 2016. PMID: 28144512; PMCID: PMC5238670.
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Beilstein J Nanotechnol. 2016 Nov 08;7:1620-1641. doi: 10.3762/bjnano.7.155. eCollection 2016.

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells.

Beilstein journal of nanotechnology

Alexandra M Greiner, Adria Sales, Hao Chen, Sarah A Biela, Dieter Kaufmann, Ralf Kemkemer

Affiliations

  1. Karlsruhe Institute of Technology (KIT), Institute of Zoology, Department of Cell and Neurobiology, Haid-und-Neu-Strasse 9, 76131 Karlsruhe, Germany.
  2. now at: Pforzheim University, School of Engineering, Tiefenbronner Strasse 65, 75175 Pforzheim, Germany.
  3. Max Planck Institute for Intelligent Systems, Department of New Materials and Biosystems, Heisenbergstrasse 3, 70569 Stuttgart, Germany.
  4. Universitätsklinikum Ulm, Institut für Humangenetik, Albert Einstein Allee 11, 89070 Ulm, Germany.
  5. Reutlingen University, Faculty of Applied Chemistry, Alteburgstrasse 150, 72762 Reutlingen, Germany.

PMID: 28144512 PMCID: PMC5238670 DOI: 10.3762/bjnano.7.155

Abstract

The extracellular environment of vascular cells in vivo is complex in its chemical composition, physical properties, and architecture. Consequently, it has been a great challenge to study vascular cell responses in vitro, either to understand their interaction with their native environment or to investigate their interaction with artificial structures such as implant surfaces. New procedures and techniques from materials science to fabricate bio-scaffolds and surfaces have enabled novel studies of vascular cell responses under well-defined, controllable culture conditions. These advancements are paving the way for a deeper understanding of vascular cell biology and materials-cell interaction. Here, we review previous work focusing on the interaction of vascular smooth muscle cells (SMCs) and endothelial cells (ECs) with materials having micro- and nanostructured surfaces. We summarize fabrication techniques for surface topographies, materials, geometries, biochemical functionalization, and mechanical properties of such materials. Furthermore, various studies on vascular cell behavior and their biological responses to micro- and nanostructured surfaces are reviewed. Emphasis is given to studies of cell morphology and motility, cell proliferation, the cytoskeleton and cell-matrix adhesions, and signal transduction pathways of vascular cells. We finalize with a short outlook on potential interesting future studies.

Keywords: fabrication methods; materials selection; nano- and micro-topography; vascular endothelial cells; vascular smooth muscle cells

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