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Egorov AA, Fedotov AY, Mironov AV, et al. 3D printing of mineral-polymer bone substitutes based on sodium alginate and calcium phosphate. Beilstein J Nanotechnol. 2016;7:1794-1799doi: 10.3762/bjnano.7.172.
Egorov, A. A., Fedotov, A. Y., Mironov, A. V., Komlev, V. S., Popov, V. K., & Zobkov, Y. V. (2016). 3D printing of mineral-polymer bone substitutes based on sodium alginate and calcium phosphate. Beilstein journal of nanotechnology, 71794-1799. https://doi.org/10.3762/bjnano.7.172
Egorov, Aleksey A, et al. "3D printing of mineral-polymer bone substitutes based on sodium alginate and calcium phosphate." Beilstein journal of nanotechnology vol. 7 (2016): 1794-1799. doi: https://doi.org/10.3762/bjnano.7.172
Egorov AA, Fedotov AY, Mironov AV, Komlev VS, Popov VK, Zobkov YV. 3D printing of mineral-polymer bone substitutes based on sodium alginate and calcium phosphate. Beilstein J Nanotechnol. 2016 Nov 21;7:1794-1799. doi: 10.3762/bjnano.7.172. eCollection 2016. PMID: 28144529; PMCID: PMC5238623.
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Beilstein J Nanotechnol. 2016 Nov 21;7:1794-1799. doi: 10.3762/bjnano.7.172. eCollection 2016.

3D printing of mineral-polymer bone substitutes based on sodium alginate and calcium phosphate.

Beilstein journal of nanotechnology

Aleksey A Egorov, Alexander Yu Fedotov, Anton V Mironov, Vladimir S Komlev, Vladimir K Popov, Yury V Zobkov

Affiliations

  1. A. A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninsky prospect 49, 119334, Moscow, Russia.
  2. Institute of Photonic Technologies, Federal Scientific Research Centre "Crystallography and Photonics", Russian Academy of Sciences, 2 Pionerskaya St., 142092 Troitsk, Moscow, Russia.

PMID: 28144529 PMCID: PMC5238623 DOI: 10.3762/bjnano.7.172

Abstract

We demonstrate a relatively simple route for three-dimensional (3D) printing of complex-shaped biocompatible structures based on sodium alginate and calcium phosphate (CP) for bone tissue engineering. The fabrication of 3D composite structures was performed through the synthesis of inorganic particles within a biopolymer macromolecular network during 3D printing process. The formation of a new CP phase was studied through X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. Both the phase composition and the diameter of the CP particles depend on the concentration of a liquid component (i.e., the "ink"). The 3D printed structures were fabricated and found to have large interconnected porous systems (mean diameter ≈800 μm) and were found to possess compressive strengths from 0.45 to 1.0 MPa. This new approach can be effectively applied for fabrication of biocompatible scaffolds for bone tissue engineering constructions.

Keywords: 3D printing; bone graft; calcium phosphate; composite materials; sodium alginate; tissue engineering

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