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Lee HJ, Kim JY, Park JE, et al. Induction of Fas-Mediated Apoptosis by Interferon-γ is Dependent on Granulosa Cell Differentiation and Follicular Maturation in the Rat Ovary. Dev Reprod. 2016;20(4):315-329doi: 10.12717/DR.2016.20.4.315.
Lee, H. J., Kim, J. Y., Park, J. E., Yoon, Y. D., Tsang, B. K., & Kim, J. M. (2016). Induction of Fas-Mediated Apoptosis by Interferon-γ is Dependent on Granulosa Cell Differentiation and Follicular Maturation in the Rat Ovary. Development & reproduction, 20(4), 315-329. https://doi.org/10.12717/DR.2016.20.4.315
Lee, Hye-Jeong, et al. "Induction of Fas-Mediated Apoptosis by Interferon-γ is Dependent on Granulosa Cell Differentiation and Follicular Maturation in the Rat Ovary." Development & reproduction vol. 20,4 (2016): 315-329. doi: https://doi.org/10.12717/DR.2016.20.4.315
Lee HJ, Kim JY, Park JE, Yoon YD, Tsang BK, Kim JM. Induction of Fas-Mediated Apoptosis by Interferon-γ is Dependent on Granulosa Cell Differentiation and Follicular Maturation in the Rat Ovary. Dev Reprod. 2016 Dec;20(4):315-329. doi: 10.12717/DR.2016.20.4.315. Epub 2016 Dec 31. PMID: 28144637; PMCID: PMC5270607.
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Dev Reprod. 2016 Dec;20(4):315-329. doi: 10.12717/DR.2016.20.4.315. Epub 2016 Dec 31.

Induction of Fas-Mediated Apoptosis by Interferon-γ is Dependent on Granulosa Cell Differentiation and Follicular Maturation in the Rat Ovary.

Development & reproduction

Hye-Jeong Lee, Ji Young Kim, Ji Eun Park, Yong-Dal Yoon, Benjamin K Tsang, Jong-Min Kim

Affiliations

  1. Department of Pharmacology, College of Medicine, Dong-A University, Busan 602-714, Korea.
  2. Division of Medical Oncology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 152-703, Republic of Korea.
  3. Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Busan 602-714, Korea.
  4. Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133-791, Korea.
  5. Department of Obstetrics and Gynecology and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada K1Y 4E9.

PMID: 28144637 PMCID: PMC5270607 DOI: 10.12717/DR.2016.20.4.315

Abstract

Fas ligand (FasL) and its receptor Fas have been implicated in granulosa cell apoptosis during follicular atresia. Although interferon-gamma (IFN-γ) is believed to be involved in the regulation Fas expression in differentiated granulosa or granulosa-luteal cells, the expression of this cytokine and its role in the regulation of the granulosa cell Fas/FasL system and apoptosis during follicular maturation have not been thoroughly investigated. In the present study, we have examined the presence of IFN-γ in ovarian follicles at different stage of development by immunohistochemistry and related their relative intensities with follicular expression of Fas and FasL, and with differences in granulosa cell sensitivity to Fas activation by exogenous agonistic Anti-Fas monoclonal antibody (Fas mAb). Although IFN-γ immunostaining was detectable in oocyte and granulosa cells in antral follicles, most intense immunoreactivity for the cytokine was observed in these cells of preantral follicles. Intense immunoreactivity for IFN-γ was most evident in granulosa cells of atretic early antral follicles where increased Fas and FasL expression and apoptosis were also observed. Whereas low concentrations of IFN-γ (10-100 U/mL) significantly increased Fas expression in undifferentiated granulosa cells (from preantral or very early antral follicles)

Keywords: Apoptosis; Fas; Granulosa cells; Interferon-γ; Ovary

References

  1. Endocrinology. 1996 Apr;137(4):1447-56 - PubMed
  2. Endocrinology. 1991 Mar;128(3):1223-8 - PubMed
  3. Biol Reprod. 1999 Apr;60(4):797-804 - PubMed
  4. Cell. 1995 May 19;81(4):505-12 - PubMed
  5. J Clin Endocrinol Metab. 1998 Jan;83(1):179-86 - PubMed
  6. Mol Endocrinol. 1989 Jun;3(6):887-94 - PubMed
  7. Nature. 1985 May 16-22;315(6016):235-7 - PubMed
  8. J Endocrinol. 1992 Apr;133(1):131-9 - PubMed
  9. Biochem Biophys Res Commun. 1988 Dec 30;157(3):891-7 - PubMed
  10. Biol Reprod. 1993 Apr;48(4):707-14 - PubMed
  11. Int Rev Cytol. 1991;124:43-101 - PubMed
  12. J Exp Med. 1998 Feb 16;187(4):587-600 - PubMed
  13. J Steroid Biochem Mol Biol. 1992 Oct;43(5):439-44 - PubMed
  14. J Interferon Res. 1982;2(3):387-400 - PubMed
  15. Eur J Biochem. 1973 Jul 2;36(1):32-8 - PubMed
  16. Fertil Steril. 1994 Mar;61(3):488-95 - PubMed
  17. Endocrinology. 1998 Dec;139(12):4860-9 - PubMed
  18. J Immunol. 1998 Sep 1;161(5):2201-7 - PubMed
  19. Biol Reprod. 1994 May;50(5):1161-7 - PubMed
  20. Arch Virol. 1981;67(1):45-9 - PubMed
  21. J Biol Chem. 1988 Sep 25;263(27):13786-90 - PubMed
  22. Endocrinology. 1997 Nov;138(11):4558-66 - PubMed
  23. Cell. 1996 Jun 14;85(6):817-27 - PubMed
  24. Science. 1998 Oct 9;282(5387):290-3 - PubMed
  25. Anat Rec. 1991 Feb;229(2):177-85 - PubMed
  26. Cell. 1993 Dec 17;75(6):1169-78 - PubMed
  27. Biol Reprod. 1995 Feb;52(2):279-87 - PubMed
  28. J Cell Physiol. 1993 Mar;154(3):519-26 - PubMed
  29. Endocrinology. 1996 May;137(5):1938-48 - PubMed
  30. Endocrinology. 1998 Mar;139(3):1321-8 - PubMed
  31. Annu Rev Biochem. 1987;56:727-77 - PubMed
  32. J Cell Biol. 1992 Nov;119(3):493-501 - PubMed
  33. Hum Reprod. 1996 Apr;11(4):790-7 - PubMed
  34. J Clin Endocrinol Metab. 1996 Jul;81(7):2702-10 - PubMed
  35. Biol Reprod. 1998 May;58(5):1170-6 - PubMed
  36. Nucleic Acids Res. 1983 Mar 25;11(6):1759-71 - PubMed
  37. J Immunol. 1992 Feb 15;148(4):1274-9 - PubMed
  38. Endocrinology. 1999 May;140(5):2307-17 - PubMed
  39. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8518-22 - PubMed
  40. Biochem Biophys Res Commun. 1994 Jan 28;198(2):666-74 - PubMed
  41. Biol Reprod. 1997 Aug;57(2):420-7 - PubMed

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