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Front Microbiol. 2017 Jan 06;7:2133. doi: 10.3389/fmicb.2016.02133. eCollection 2016.

The Hog1 MAP Kinase Promotes the Recovery from Cell Cycle Arrest Induced by Hydrogen Peroxide in .

Frontiers in microbiology

Inês Correia, Rebeca Alonso-Monge, Jesús Pla

Affiliations

  1. Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid Madrid, Spain.

PMID: 28111572 PMCID: PMC5216027 DOI: 10.3389/fmicb.2016.02133

Abstract

Eukaryotic cell cycle progression in response to environmental conditions is controlled via specific checkpoints. Signal transduction pathways mediated by MAPKs play a crucial role in sensing stress. For example, the canonical MAPKs Mkc1 (of the cell wall integrity pathway), and Hog1 (of the HOG pathway), are activated upon oxidative stress. In this work, we have analyzed the effect of oxidative stress induced by hydrogen peroxide on cell cycle progression in

Keywords: Candida albicans; MAPK; cell cycle; oxidative stress; signaling

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