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Front Cell Neurosci. 2016 Dec 26;10:290. doi: 10.3389/fncel.2016.00290. eCollection 2016.

FUS Mislocalization and Vulnerability to DNA Damage in ALS Patients Derived hiPSCs and Aging Motoneurons.

Frontiers in cellular neuroscience

Julia Higelin, Maria Demestre, Stefan Putz, Jan P Delling, Christian Jacob, Anne-Kathrin Lutz, Julia Bausinger, Anne-Kathrin Huber, Moritz Klingenstein, Gotthold Barbi, Günter Speit, Annemarie Huebers, Jochen H Weishaupt, Andreas Hermann, Stefan Liebau, Albert C Ludolph, Tobias M Boeckers

Affiliations

  1. Institute for Anatomy and Cell Biology, Ulm University Ulm, Germany.
  2. Institute for Anatomy and Cell Biology, Ulm UniversityUlm, Germany; Department of Neurology, Ulm UniversityUlm, Germany.
  3. Institute for Human Genetics, Ulm University Ulm, Germany.
  4. Institute of Neuroanatomy, Eberhard Karls University of Tübingen Tübingen, Germany.
  5. Department of Neurology, Ulm University Ulm, Germany.
  6. Department of Neurology, Technische Universität DresdenDresden, Germany; German Center for Neurodegenerative DiseasesDresden, Germany; Center for Regenerative Therapies Dresden, Technische Universität DresdenDresden, Germany.

PMID: 28082870 PMCID: PMC5183648 DOI: 10.3389/fncel.2016.00290

Abstract

Mutations within the

Keywords: ALS; DNA damage; FTLD; FUS; hiPSC; motoneuron; neurodegeneration

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