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Ramírez-López MT, Arco R, Decara J, et al. Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators. Front Behav Neurosci. 2016;10:241doi: 10.3389/fnbeh.2016.00241.
Ramírez-López, M. T., Arco, R., Decara, J., Vázquez, M., Rivera, P., Blanco, R. N., Alén, F., Gómez de Heras, R., Suárez, J., & Rodríguez de Fonseca, F. (2016). Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators. Frontiers in behavioral neuroscience, 10241. https://doi.org/10.3389/fnbeh.2016.00241
Ramírez-López, María T, et al. "Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators." Frontiers in behavioral neuroscience vol. 10 (2016): 241. doi: https://doi.org/10.3389/fnbeh.2016.00241
Ramírez-López MT, Arco R, Decara J, Vázquez M, Rivera P, Blanco RN, Alén F, Gómez de Heras R, Suárez J, Rodríguez de Fonseca F. Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators. Front Behav Neurosci. 2016 Dec 27;10:241. doi: 10.3389/fnbeh.2016.00241. eCollection 2016. PMID: 28082878; PMCID: PMC5187359.
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Front Behav Neurosci. 2016 Dec 27;10:241. doi: 10.3389/fnbeh.2016.00241. eCollection 2016.

Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators.

Frontiers in behavioral neuroscience

María T Ramírez-López, Rocío Arco, Juan Decara, Mariam Vázquez, Patricia Rivera, Rosario Noemi Blanco, Francisco Alén, Raquel Gómez de Heras, Juan Suárez, Fernando Rodríguez de Fonseca

Affiliations

  1. Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de MadridMadrid, Spain; Hospital Universitario de GetafeMadrid, Spain.
  2. Instituto de Investigación Biomédica de Málaga (IBIMA), Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de Málaga Málaga, Spain.
  3. Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de MadridMadrid, Spain; Instituto de Investigación Biomédica de Málaga (IBIMA), Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de MálagaMálaga, Spain.
  4. Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid Madrid, Spain.
  5. Instituto de Investigación Biomédica de Málaga (IBIMA), Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de MálagaMálaga, Spain; Departamento de Biología Celular, Genética y Fisiología, Instituto de Investigación Biomédica de Málaga (IBIMA), Facultad de Ciencias, Universidad de MálagaMálaga, Spain.

PMID: 28082878 PMCID: PMC5187359 DOI: 10.3389/fnbeh.2016.00241

Abstract

Maternal malnutrition causes long-lasting alterations in feeding behavior and energy homeostasis in offspring. It is still unknown whether both, the endocannabinoid (eCB) machinery and the lipid metabolism are implicated in long-term adaptive responses to fetal reprogramming caused by maternal undernutrition. We investigated the long-term effects of maternal exposure to a 20% standard diet restriction during preconceptional and gestational periods on the metabolically-relevant tissues hypothalamus, liver, and perirenal fat (PAT) of male and female offspring at adulthood. The adult male offspring from calorie-restricted dams (RC males) exhibited a differential response to the CB1 antagonist AM251 in a chocolate preference test as well as increased body weight, perirenal adiposity, and plasma levels of triglycerides, LDL, VLDL, bilirubin, and leptin. The gene expression of the cannabinoid receptors

Keywords: CB1 receptor; adipose tissue; hypothalamus; lipogenesis; lipoproteins; liver; maternal diet; β-oxidation

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