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Front Psychiatry. 2016 Dec 27;7:203. doi: 10.3389/fpsyt.2016.00203. eCollection 2016.

Social Phobia Is Associated with Delayed Onset of Chickenpox, Measles, and Mumps Infections.

Frontiers in psychiatry

Vladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Mario Müller, Wolfram Kawohl, Wulf Rössler, Enrique Castelao, Caroline Vandeleur, Roland von Känel, Margot Mutsch, Roselind Lieb, Martin Preisig

Affiliations

  1. Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland; Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zürich, Switzerland.
  2. Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich , Zürich , Switzerland.
  3. Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland; Collegium Helveticum, Swiss Federal Institute of Technology, University of Zürich, Zürich, Switzerland; Institute of Psychiatry, Laboratory of Neuroscience (LIM27), University of Sao Paulo, Sao Paulo, Brazil.
  4. Department of Psychiatry, University Hospital of Lausanne , Lausanne , Switzerland.
  5. Department of Neurology, Bern University Hospital, Clinic Barmelweid , Barmelweid , Switzerland.
  6. Epidemiology, Biostatistics and Prevention Institute, University of Zürich , Zürich , Switzerland.
  7. Department of Psychology, Division of Clinical Psychology and Epidemiology, University of Basel , Basel , Switzerland.

PMID: 28082921 PMCID: PMC5186793 DOI: 10.3389/fpsyt.2016.00203

Abstract

OBJECTIVE: Evidence showing that infectious diseases in childhood play an important role in the etiopathogenesis of neurodevelopmental and other mental disorders is growing. The aim of this study was to explore the timing of common childhood diseases in early-onset anxiety disorders.

MATERIALS AND METHODS: We analyzed data from PsyCoLaus, a large Swiss Population Cohort Study (

RESULTS: The timing of viral childhood diseases (chickenpox, measles, and mumps) was consistently delayed in social phobia, notably both in men and women. We found no evidence for a reversed sequence of onset of phobia symptoms before that of the infections included.

CONCLUSION: Social phobia was the only early anxiety disorder to show an association with a delayed onset of common viral childhood diseases.

Keywords: anxiety disorders; childhood diseases; epidemiology; infectious diseases; social phobia

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