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Front Immunol. 2016 Dec 27;7:651. doi: 10.3389/fimmu.2016.00651. eCollection 2016.

Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model.

Frontiers in immunology

Carolina Iraporda, David E Romanin, Ana A Bengoa, Agustina J Errea, Delphine Cayet, Benoit Foligné, Jean-Claude Sirard, Graciela L Garrote, Analía G Abraham, Martín Rumbo

Affiliations

  1. Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, UNLP-CONICET-CIC.PBA) , La Plata , Argentina.
  2. Instituto de Estudios Inmunológicos y Fisopatológicos (IIFP, UNLP-CONICET) , La Plata , Argentina.
  3. CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, University of Lille , Lille , France.
  4. Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA, UNLP-CONICET-CIC.PBA), La Plata, Argentina; Área Bioquímica y Control de Alimentos, Facultad de Ciencias Exactas, UNLP, La Plata, Argentina.

PMID: 28082985 PMCID: PMC5187354 DOI: 10.3389/fimmu.2016.00651

Abstract

Lactate has long been considered as a metabolic by-product of cells. Recently, this view has been changed by the observation that lactate can act as a signaling molecule and regulates critical functions of the immune system. We previously identified lactate as the component responsible for the modulation of innate immune epithelial response of fermented milk supernatants

Keywords: TNBS-induced colitis; flagellin; immunomodulation; innate immunity; lactate

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