Display options
Cite
Fatima SS, Chaudhry B, Khan TA, et al. KCNQ1 rs2237895 polymorphism is associated with Gestational Diabetes in Pakistani Women. Pak J Med Sci. 2016;32(6):1380-1385doi: 10.12669/pjms.326.11052.
Fatima, S. S., Chaudhry, B., Khan, T. A., & Farooq, S. (2016). KCNQ1 rs2237895 polymorphism is associated with Gestational Diabetes in Pakistani Women. Pakistan journal of medical sciences, 32(6), 1380-1385. https://doi.org/10.12669/pjms.326.11052
Fatima, Syeda Sadia, et al. "KCNQ1 rs2237895 polymorphism is associated with Gestational Diabetes in Pakistani Women." Pakistan journal of medical sciences vol. 32,6 (2016): 1380-1385. doi: https://doi.org/10.12669/pjms.326.11052
Fatima SS, Chaudhry B, Khan TA, Farooq S. KCNQ1 rs2237895 polymorphism is associated with Gestational Diabetes in Pakistani Women. Pak J Med Sci. 2016 Nov-Dec;32(6):1380-1385. doi: 10.12669/pjms.326.11052. PMID: 28083030; PMCID: PMC5216286.
Copy Download .nbib Format: NLM
Share it on

Pak J Med Sci. 2016 Nov-Dec;32(6):1380-1385. doi: 10.12669/pjms.326.11052.

KCNQ1 rs2237895 polymorphism is associated with Gestational Diabetes in Pakistani Women.

Pakistan journal of medical sciences

Syeda Sadia Fatima, Bushra Chaudhry, Taseer Ahmed Khan, Saad Farooq

Affiliations

  1. Syeda Sadia Fatima, MBBS, MPhil, PhD, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistani.
  2. Bushra Chaudhry, PhD, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistani.
  3. Taseer Ahmed Khan, PhD. Department of Physiology, University of Karachi, Karachi, Pakistan.
  4. Saad Farooq, MBBS Year 5 Student, Medical College, Pakistan.

PMID: 28083030 PMCID: PMC5216286 DOI: 10.12669/pjms.326.11052

Abstract

BACKGROUND AND OBJECTIVE: Genetic studies on gestational diabetes (GDM) are relatively scarce; moreover, limited data is available for KCNQ1 polymorphism in Pakistani pregnant women. We aimed to determine the frequency of KCNQ1 rs2237895 in GDM and normal pregnant controls and its association with GDM-related phenotypes.

METHODS: A total of 637 pregnant females (429 controls and 208 cases) in their second trimester were classified according to the International Association of the Diabetes and Pregnancy Study criteria in this study. Their blood samples were genotyped for KCNQ1 SNP rs2237895 using PCR-RFLP method and sequencing. Fasting and two hour-post glucose load blood levels, serum HbA1c, insulin, and anthropometric assessment was performed.: Pearson's Chi Square test, Mann- Whitney U test, and regression analyses were performed. A p-value of <0.05 was considered significant.

RESULTS: The variant genotyped was in Hardy-Weinberg equilibrium (p>0.05). The rs2237895 showed an association with GDM (OR 2.281; 1.388-3.746: p <0.001) and remained significant after multiple adjustments for age and body mass index (OR 2.068; 1.430-2.997: p=0.005). The C allele showed positive association with insulin level, and HOMA-IR in study subjects.

CONCLUSIONS: This study identifies that KCNQ1 rs2237895 polymorphisms might be associated with risk of GDM in Pakistani population and that it is related to higher glucose levels and insulin resistance. Further large scale studies are required to consolidate on the functional aspect of this polymorphism.

Keywords: Body mass index; GWAS; Gestational Diabetes Mellitus; KCNQ1; SNP

Conflict of interest statement

Declaration of interest: The authors declare that they have no conflict of interest.

References

  1. Diabetologia. 2009 Nov;52(11):2466-8 - PubMed
  2. Circulation. 2007 May 15;115(19):2481-9 - PubMed
  3. Horm Res Paediatr. 2010;74(5):333-8 - PubMed
  4. J Clin Endocrinol Metab. 2010 Jan;95(1):445-9 - PubMed
  5. Yonsei Med J. 2013 Mar 1;54(2):352-7 - PubMed
  6. Nat Genet. 2008 Sep;40(9):1092-7 - PubMed
  7. Horm Metab Res. 2010 Feb;42(2):149-51 - PubMed
  8. J Pak Med Assoc. 1991 Feb;41(2):31-3 - PubMed
  9. Diabet Med. 2016 Aug;33(8):1112-7 - PubMed
  10. Diabetes Care. 2007 Jul;30 Suppl 2:S141-6 - PubMed
  11. Indian J Endocrinol Metab. 2011 Jul;15(3):191-3 - PubMed
  12. Diabetologia. 2011 Jun;54(6):1368-74 - PubMed
  13. PLoS One. 2015 Jun 03;10(6):e0128901 - PubMed
  14. Nat Genet. 2008 Sep;40(9):1098-102 - PubMed
  15. Diabetologia. 2009 Jul;52(7):1315-21 - PubMed
  16. Mol Endocrinol. 2001 Aug;15(8):1423-35 - PubMed
  17. Diabetologia. 2009 Feb;52(2):253-61 - PubMed
  18. Mol Biol Rep. 2010 Jan;37(1):207-12 - PubMed
  19. Eur J Clin Nutr. 2007 Jun;61(6):736-42 - PubMed
  20. PLoS One. 2009 Jun 11;4(6):e5872 - PubMed
  21. Pharmacol Ther. 2001 Apr;90(1):1-19 - PubMed
  22. BMC Med Genet. 2011 Jan 24;12:18 - PubMed
  23. Am J Clin Nutr. 1994 Jul;60(1):23-8 - PubMed
  24. Science. 2003 Jan 10;299(5604):251-4 - PubMed

Publication Types