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Fournier JC, Chase HW, Almeida J, et al. Within- and Between-Session Changes in Neural Activity During Emotion Processing in Unipolar and Bipolar Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016;1(6):518-527doi: 10.1016/j.bpsc.2016.03.005.
Fournier, J. C., Chase, H. W., Almeida, J., & Phillips, M. L. (2016). Within- and Between-Session Changes in Neural Activity During Emotion Processing in Unipolar and Bipolar Depression. Biological psychiatry. Cognitive neuroscience and neuroimaging, 1(6), 518-527. https://doi.org/10.1016/j.bpsc.2016.03.005
Fournier, Jay C, et al. "Within- and Between-Session Changes in Neural Activity During Emotion Processing in Unipolar and Bipolar Depression." Biological psychiatry. Cognitive neuroscience and neuroimaging vol. 1,6 (2016): 518-527. doi: https://doi.org/10.1016/j.bpsc.2016.03.005
Fournier JC, Chase HW, Almeida J, Phillips ML. Within- and Between-Session Changes in Neural Activity During Emotion Processing in Unipolar and Bipolar Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Nov;1(6):518-527. doi: 10.1016/j.bpsc.2016.03.005. PMID: 28083566; PMCID: PMC5220672.
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Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Nov;1(6):518-527. doi: 10.1016/j.bpsc.2016.03.005.

Within- and Between-Session Changes in Neural Activity During Emotion Processing in Unipolar and Bipolar Depression.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Jay C Fournier, Henry W Chase, Jorge Almeida, Mary L Phillips

Affiliations

  1. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  2. Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, USA.

PMID: 28083566 PMCID: PMC5220672 DOI: 10.1016/j.bpsc.2016.03.005

Abstract

BACKGROUND: Bipolar disorder (BD) and unipolar depression (UD) can be difficult to distinguish clinically, particularly during episodes of depression. In this study we test for differences between BD, UD, and healthy control (HC) adults regarding within- and between-session changes in BOLD response during implicit emotional processing.

METHODS: During fMRI, HC adults (N=19) and depressed adults with UD (N=19) and BD (N=16) performed an implicit emotion-processing task. Each participant was scanned twice, separated by 6-months, resulting in 108 scans. BOLD response and linear change in BOLD response were examined within and between sessions.

RESULTS: We observed within-session linear decreases in BOLD signal (irrespective of group, condition, or session) in the left amygdala, a right-sided temporo-parietal region, and a right-sided fronto-insular region. Furthermore, we observed group differences in within-session BOLD signal change (p<0.05, FWE corrected) in a left-sided striatal-insular-thalamic region. Individuals with BD demonstrated a linear decrease in BOLD signal compared to HC (p<0.008, FWE corrected) across this region and compared to UD in the posterior insula portion of the region (p<0.008, FWE corrected). Finally, we observed main effects of emotional valence in bilateral visuo-spatial processing regions as well as in the left and right amygdala.

CONCLUSIONS: Individuals with BD demonstrated linear attenuation of BOLD response to emotional stimuli within left-sided striatal-insular-thalamic regions. Individuals with BD may either have experienced abnormal habituation in this region or disengaged quickly from processing the emotional stimuli, despite comparable task performance. This pattern may represent an underlying pathophysiological process associated with BD that differs from UD.

Keywords: BOLD attenuation; Bipolar Disorder; Emotion processing; Major Depressive Disorder; Whole brain analysis; fMRI

Conflict of interest statement

Financial Disclosures MLP serves as a consultant to Roche Pharmaceuticals. All other authors report no biomedical financial interests or potential conflicts of interest.

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