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Ari G, Cherukuri S, Namasivayam A. Epigenetics and Periodontitis: A Contemporary Review. J Clin Diagn Res. 2016;10(11):ZE07-ZE09doi: 10.7860/JCDR/2016/21025.8864.
Ari, G., Cherukuri, S., & Namasivayam, A. (2016). Epigenetics and Periodontitis: A Contemporary Review. Journal of clinical and diagnostic research : JCDR, 10(11), ZE07-ZE09. https://doi.org/10.7860/JCDR/2016/21025.8864
Ari, Geetha, et al. "Epigenetics and Periodontitis: A Contemporary Review." Journal of clinical and diagnostic research : JCDR vol. 10,11 (2016): ZE07-ZE09. doi: https://doi.org/10.7860/JCDR/2016/21025.8864
Ari G, Cherukuri S, Namasivayam A. Epigenetics and Periodontitis: A Contemporary Review. J Clin Diagn Res. 2016 Nov;10(11):ZE07-ZE09. doi: 10.7860/JCDR/2016/21025.8864. Epub 2016 Nov 01. PMID: 28050521; PMCID: PMC5198474.
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J Clin Diagn Res. 2016 Nov;10(11):ZE07-ZE09. doi: 10.7860/JCDR/2016/21025.8864. Epub 2016 Nov 01.

Epigenetics and Periodontitis: A Contemporary Review.

Journal of clinical and diagnostic research : JCDR

Geetha Ari, Sandhya Cherukuri, Ambalavanan Namasivayam

Affiliations

  1. Reader, Department of Periodontology, Meenakshi Ammal Dental College and Hospital , Chennai, Tamil Nadu, India .
  2. Postgraduate Student, Meenakshi Ammal Dental College and Hospital , Chennai, Tamil Nadu, India .
  3. Professor and Head, Department of Periodontology, Meenakshi Ammal Dental College and Hospital , Chennai, Tamil Nadu, India .

PMID: 28050521 PMCID: PMC5198474 DOI: 10.7860/JCDR/2016/21025.8864

Abstract

Periodontitis is characterized by infection and inflammation of the tooth supporting structures. Few signs of susceptibility and recurrence after treatment are seen due to the outgrowth of various pathogenic microorganisms. Many studies have been done to understand the genetic basis of periodontal disease. An increased risk for periodontitis has been shown with the variations in genes related to the inflammatory response. Interestingly, some of the genes regulated by epigenetic modifications are modified in response to environmental stimuli. Conditions such as cancer, autoimmune or inflammatory diseases have been dispensed by epigenetic mechanisms. The understanding of these molecular mechanisms and the early detection of susceptibility may guide in future periodontal disease treatment and prevention.

Keywords: DNA methylation; Future implications; Histone modification

References

  1. J Dent Res. 2010 Feb;89(2):133-7 - PubMed
  2. Restor Dent Endod. 2015 Feb;40(1):14-22 - PubMed
  3. J Periodontol. 2010 Sep;81(9):1336-41 - PubMed
  4. Eur J Oral Sci. 2012 Feb;120(1):14-20 - PubMed
  5. J Dent Res. 2011 Jan;90(1):9-17 - PubMed
  6. J Periodontol. 2013 Nov;84(11):1606-16 - PubMed
  7. Immunobiology. 2013 Jul;218(7):1012-7 - PubMed
  8. Periodontol 2000. 2014 Feb;64(1):95-110 - PubMed
  9. Exp Cell Res. 2013 Jun 10;319(10):1534-43 - PubMed
  10. Hum Immunol. 2013 Sep;74(9):1231-6 - PubMed
  11. Cancer Res. 2007 Feb 1;67(3):946-50 - PubMed
  12. J Periodontal Res. 2011 Dec;46(6):697-703 - PubMed
  13. Mutat Res. 2008 Jul-Aug;659(1-2):15-30 - PubMed
  14. J Dent Res. 2014 Jul;93(7):657-62 - PubMed
  15. J Periodontal Implant Sci. 2013 Jun;43(3):111-20 - PubMed
  16. J Periodontol. 2008 Aug;79(8 Suppl):1514-9 - PubMed
  17. Cardiovasc Res. 2011 Jun 1;90(3):430-40 - PubMed
  18. Periodontol 2000. 2005;38:135-87 - PubMed
  19. Genes Dev. 2009 Apr 1;23(7):781-3 - PubMed
  20. J Immunol. 2009 Mar 15;182(6):3688-95 - PubMed
  21. J Dent Res. 2009 May;88(5):400-8 - PubMed
  22. J Clin Periodontol. 2010 Nov;37(11):953-61 - PubMed
  23. Nat Rev Genet. 2009 Nov;10 (11):805-11 - PubMed
  24. Trends Plant Sci. 2006 Apr;11(4):199-208 - PubMed
  25. J Transl Med. 2010 Nov 04;8:110 - PubMed

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