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Yoshida Y, Yoshizumi T, Wang H, et al. Liver transplantation for cryptogenic liver failure caused by diffuse hepatic angiosarcoma: case report. Surg Case Rep. 2017;3(1):21doi: 10.1186/s40792-017-0296-0.
Yoshida, Y., Yoshizumi, T., Wang, H., Sakata, K., Shimokawa, M., Kurihara, T., Motomura, T., Itoh, S., Harada, N., Harimoto, N., Ikegami, T., Uchiyama, H., Soejima, Y., & Maehara, Y. (2017). Liver transplantation for cryptogenic liver failure caused by diffuse hepatic angiosarcoma: case report. Surgical case reports, 3(1), 21. https://doi.org/10.1186/s40792-017-0296-0
Yoshida, Yoshihiro, et al. "Liver transplantation for cryptogenic liver failure caused by diffuse hepatic angiosarcoma: case report." Surgical case reports vol. 3,1 (2017): 21. doi: https://doi.org/10.1186/s40792-017-0296-0
Yoshida Y, Yoshizumi T, Wang H, Sakata K, Shimokawa M, Kurihara T, Motomura T, Itoh S, Harada N, Harimoto N, Ikegami T, Uchiyama H, Soejima Y, Maehara Y. Liver transplantation for cryptogenic liver failure caused by diffuse hepatic angiosarcoma: case report. Surg Case Rep. 2017 Dec;3(1):21. doi: 10.1186/s40792-017-0296-0. Epub 2017 Feb 01. PMID: 28150220; PMCID: PMC5289124.
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Surg Case Rep. 2017 Dec;3(1):21. doi: 10.1186/s40792-017-0296-0. Epub 2017 Feb 01.

Liver transplantation for cryptogenic liver failure caused by diffuse hepatic angiosarcoma: case report.

Surgical case reports

Yoshihiro Yoshida, Tomoharu Yoshizumi, Huanlin Wang, Kazuhito Sakata, Masahiro Shimokawa, Takeshi Kurihara, Takashi Motomura, Shinji Itoh, Noboru Harada, Norifumi Harimoto, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara

Affiliations

  1. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
  2. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. [email protected].

PMID: 28150220 PMCID: PMC5289124 DOI: 10.1186/s40792-017-0296-0

Abstract

BACKGROUND: Primary hepatic angiosarcoma is a non-epithelial malignancy derived from sinusoidal endothelial cells, accounting for approximately 1.8% of primary hepatic malignancies. Diagnosis of primary hepatic angiosarcoma is complicated by difficulties in the qualitative radiological assessment of these tumors. Prognosis is very poor due to local recurrence and distant metastasis after liver resection or liver transplantation (LT).

CASE PRESENTATION: This case report describes two patients with primary hepatic angiosarcoma who were diagnosed by histopathological examination of the explanted liver after LT. One patient had undergone living donor LT, and the other had undergone deceased donor LT. Neither showed evidence of malignancy on the pre-operative imaging tests.

CONCLUSIONS: Hepatic angiosarcoma has a very high relapse rate after LT. Pre-transplant liver biopsy may be necessary to distinguish diffuse hepatic angiosarcoma from tumors of other origin in patients with cryptogenic liver failure.

Keywords: Cryptogenic liver failure; Deceased donor liver transplantation; Diffuse hepatic angiosarcoma; Living donor liver transplantation

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