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Silveira FM, Etges A, Correa MB, et al. Microscopic Evaluation of the Effect of Oral Microbiota on the Development of Bisphosphonate-Related Osteonecrosis of the Jaws in Rats. J Oral Maxillofac Res. 2016;7(4):e3doi: 10.5037/jomr.2016.7403.
Silveira, F. M., Etges, A., Correa, M. B., & Vasconcelos, A. C. (2016). Microscopic Evaluation of the Effect of Oral Microbiota on the Development of Bisphosphonate-Related Osteonecrosis of the Jaws in Rats. Journal of oral & maxillofacial research, 7(4), e3. https://doi.org/10.5037/jomr.2016.7403
Silveira, Felipe M, et al. "Microscopic Evaluation of the Effect of Oral Microbiota on the Development of Bisphosphonate-Related Osteonecrosis of the Jaws in Rats." Journal of oral & maxillofacial research vol. 7,4 (2016): e3. doi: https://doi.org/10.5037/jomr.2016.7403
Silveira FM, Etges A, Correa MB, Vasconcelos AC. Microscopic Evaluation of the Effect of Oral Microbiota on the Development of Bisphosphonate-Related Osteonecrosis of the Jaws in Rats. J Oral Maxillofac Res. 2016 Dec 28;7(4):e3. doi: 10.5037/jomr.2016.7403. eCollection 2016. PMID: 28154747; PMCID: PMC5279769.
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J Oral Maxillofac Res. 2016 Dec 28;7(4):e3. doi: 10.5037/jomr.2016.7403. eCollection 2016.

Microscopic Evaluation of the Effect of Oral Microbiota on the Development of Bisphosphonate-Related Osteonecrosis of the Jaws in Rats.

Journal of oral & maxillofacial research

Felipe M Silveira, Adriana Etges, Marcos B Correa, Ana Carolina U Vasconcelos

Affiliations

  1. Dental College, Federal University of Pelotas - UFPel, Rio Grande do Sul, Porto Alegre Brazil.

PMID: 28154747 PMCID: PMC5279769 DOI: 10.5037/jomr.2016.7403

Abstract

OBJECTIVES: Osteonecrosis of the jaws is a side effect associated with the use of bisphosphonates. Using histologic analysis, this study aimed to evaluate the influence of microbial colonies in the development of osteonecrosis in the jaws of rats subjected to nitrogenous and non-nitrogenous bisphosphonates, undergoing surgical procedures.

MATERIAL AND METHODS: Thirty-four rats (

RESULTS: Osteonecrosis was induced in the test groups. There was no statistically significant association between the presence of microbial colonies and the presence of non-vital bone (Kruskal-Wallis, P > 0.05).

CONCLUSIONS: Use of zoledronic acid was associated with non-vital bone and the results suggested that the presence of microbial colonies does not lead to osteonecrosis.

Keywords: bisphosphonate-associated osteonecrosis of the jaw; diphosphonates; infection

References

  1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Oct;102(4):433-41 - PubMed
  2. Crit Rev Oncol Hematol. 2007 Dec;64(3):198-207 - PubMed
  3. Osteoporos Int. 2016 Mar;27(3):853-9 - PubMed
  4. Oral Oncol. 2012 May;48(5):469-74 - PubMed
  5. Head Neck. 2011 Feb;33(2):199-207 - PubMed
  6. Oral Dis. 2012 Jan;18(1):85-95 - PubMed
  7. J Oral Maxillofac Surg. 2014 Oct;72(10):1938-56 - PubMed
  8. Virchows Arch. 2007 Dec;451(6):1009-17 - PubMed
  9. Ann N Y Acad Sci. 2011 Feb;1218:38-46 - PubMed
  10. J Oral Pathol Med. 2005 Nov;34(10):613-7 - PubMed
  11. J Oral Maxillofac Surg. 2012 Jul;70(7):1573-83 - PubMed
  12. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Mar;109(3):385-91 - PubMed
  13. Pediatrics. 2007 Mar;119 Suppl 2:S150-62 - PubMed
  14. Free Radic Biol Med. 2014 Dec;77:249-57 - PubMed
  15. J Oral Maxillofac Surg. 2008 Apr;66(4):767-75 - PubMed
  16. Case Rep Med. 2014;2014:281313 - PubMed
  17. Int J Dent. 2014;2014:192320 - PubMed
  18. Oral Oncol. 2012 Jan;48(1):79-84 - PubMed
  19. Oral Maxillofac Surg Clin North Am. 2015 Nov;27(4):479-87 - PubMed
  20. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov;108(5):738-46 - PubMed
  21. Clin Radiol. 2008 Jan;63(1):71-7 - PubMed
  22. J Plast Reconstr Aesthet Surg. 2008;61(1):99-106 - PubMed
  23. Laryngoscope. 2009 Feb;119(2):323-9 - PubMed
  24. J Oral Maxillofac Surg. 2005 Nov;63(11):1567-75 - PubMed
  25. Otol Neurotol. 2012 Oct;33(8):1308-14 - PubMed
  26. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 May;115(5):660-6 - PubMed
  27. Arch Oral Biol. 2014 Aug;59(8):790-9 - PubMed
  28. Int J Dent. 2014;2014:869067 - PubMed
  29. Infect Immun. 1996 Jul;64(7):2371-80 - PubMed
  30. J Oral Maxillofac Surg. 2009 May;67(5 Suppl):61-70 - PubMed
  31. J Oral Maxillofac Surg. 2003 Sep;61(9):1115-7 - PubMed

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