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Sehgal A, Malikiwi A, Paul E, et al. A new look at bronchopulmonary dysplasia: postcapillary pathophysiology and cardiac dysfunction. Pulm Circ. 2016;6(4):508-515doi: 10.1086/688641.
Sehgal, A., Malikiwi, A., Paul, E., Tan, K., & Menahem, S. (2016). A new look at bronchopulmonary dysplasia: postcapillary pathophysiology and cardiac dysfunction. Pulmonary circulation, 6(4), 508-515. https://doi.org/10.1086/688641
Sehgal, Arvind, et al. "A new look at bronchopulmonary dysplasia: postcapillary pathophysiology and cardiac dysfunction." Pulmonary circulation vol. 6,4 (2016): 508-515. doi: https://doi.org/10.1086/688641
Sehgal A, Malikiwi A, Paul E, Tan K, Menahem S. A new look at bronchopulmonary dysplasia: postcapillary pathophysiology and cardiac dysfunction. Pulm Circ. 2016 Dec;6(4):508-515. doi: 10.1086/688641. PMID: 28090292; PMCID: PMC5210072.
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Pulm Circ. 2016 Dec;6(4):508-515. doi: 10.1086/688641.

A new look at bronchopulmonary dysplasia: postcapillary pathophysiology and cardiac dysfunction.

Pulmonary circulation

Arvind Sehgal, Andra Malikiwi, Eldho Paul, Kenneth Tan, Samuel Menahem

Affiliations

  1. Monash Newborn, Monash Children's Hospital, Monash Health, Melbourne, Australia; Department of Paediatrics, Monash University, Melbourne, Australia.
  2. Monash Newborn, Monash Children's Hospital, Monash Health, Melbourne, Australia.
  3. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; and Clinical Haematology Department, Alfred Hospital, Melbourne, Australia.
  4. Department of Paediatrics, Monash University, Melbourne, Australia; Paediatric and Foetal Cardiac Units, Monash Medical Centre, Monash Health, Melbourne, Australia.

PMID: 28090292 PMCID: PMC5210072 DOI: 10.1086/688641

Abstract

Pulmonary hypertension (PH) and right ventricular function are the focus of cardiovascular effects of bronchopulmonary dysplasia (BPD). We assessed cardiac indexes reflecting systemic afterload and pulmonary venous back pressure as pathophysiologic factors. Cardiac parameters were measured by conventional echocardiography in 20 preterm infants with severe BPD and compared with those of 10 preterm infants with no BPD and 20 healthy term infants. In infants with severe BPD, PH was noted in 5 (25%) by tricuspid regurgitation Doppler jet ≥2.8 m/s and in 15 (75%) by time to peak velocity/right ventricular ejection time <0.34. Among systemic cardiac indexes, significant impairment of diastolic measures was noted in the BPD group compared with infants with no BPD and term infants. The significance persisted after adjusting for gestational age and birth weight. These included transmitral E/A ratio (1.07 ± 0.07 vs. 0.91 ± 0.04 vs. 0.89 ± 0.09;

Keywords: cardiac function; chronic lung disease; infants; pulmonary hypertension

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