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Berland C, Cansell C, Hnasko TS, et al. Dietary triglycerides as signaling molecules that influence reward and motivation. Curr Opin Behav Sci. 2016;9:126-135doi: 10.1016/j.cobeha.2016.03.005.
Berland, C., Cansell, C., Hnasko, T. S., Magnan, C., & Luquet, S. (2016). Dietary triglycerides as signaling molecules that influence reward and motivation. Current opinion in behavioral sciences, 9126-135. https://doi.org/10.1016/j.cobeha.2016.03.005
Berland, Chloé, et al. "Dietary triglycerides as signaling molecules that influence reward and motivation." Current opinion in behavioral sciences vol. 9 (2016): 126-135. doi: https://doi.org/10.1016/j.cobeha.2016.03.005
Berland C, Cansell C, Hnasko TS, Magnan C, Luquet S. Dietary triglycerides as signaling molecules that influence reward and motivation. Curr Opin Behav Sci. 2016 Jun;9:126-135. doi: 10.1016/j.cobeha.2016.03.005. Epub 2016 Mar 18. PMID: 28191490; PMCID: PMC5295493.
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Curr Opin Behav Sci. 2016 Jun;9:126-135. doi: 10.1016/j.cobeha.2016.03.005. Epub 2016 Mar 18.

Dietary triglycerides as signaling molecules that influence reward and motivation.

Current opinion in behavioral sciences

Chloé Berland, Céline Cansell, Thomas S Hnasko, Christophe Magnan, Serge Luquet

Affiliations

  1. Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris, France; Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health, München/Neuherberg, Germany; Div. of Metabolic Diseases, Dept. of Medicine, Technische Universität München, Germany.
  2. Université de Nice Sophia Antipolis, IPMC, Sophia Antipolis, F-06560, France; CNRS, IPMC, Sophia Antipolis, F-06560, France.
  3. Department of Neurosciences, University of California, San Diego, La Jolla CA, USA.
  4. Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris, France.

PMID: 28191490 PMCID: PMC5295493 DOI: 10.1016/j.cobeha.2016.03.005

Abstract

The reinforcing and motivational aspects of food are tied to the release of the dopamine in the mesolimbic system (ML). Free fatty acids from triglyceride (TG)-rich particles are released upon action of TG-lipases found at high levels in peripheral oxidative tissue (muscle, heart), but also in the ML. This suggests that local TG-hydrolysis in the ML might regulate food seeking and reward. Indeed, evidence now suggests that dietary TG directly target the ML to regulate amphetamine-induced locomotion and reward seeking behavior. Though the cellular mechanisms of TG action are unresolved, TG act in part through ML lipoprotein lipase, upstream of dopamine 2 receptor (D

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