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De Fusco C, Messina A, Monda V, et al. Osteopontin: Relation between Adipose Tissue and Bone Homeostasis. Stem Cells Int. 2017;2017:4045238doi: 10.1155/2017/4045238.
De Fusco, C., Messina, A., Monda, V., Viggiano, E., Moscatelli, F., Valenzano, A., Esposito, T., Sergio, C., Cibelli, G., Monda, M., & Messina, G. (2017). Osteopontin: Relation between Adipose Tissue and Bone Homeostasis. Stem cells international, 20174045238. https://doi.org/10.1155/2017/4045238
De Fusco, Carolina, et al. "Osteopontin: Relation between Adipose Tissue and Bone Homeostasis." Stem cells international vol. 2017 (2017): 4045238. doi: https://doi.org/10.1155/2017/4045238
De Fusco C, Messina A, Monda V, Viggiano E, Moscatelli F, Valenzano A, Esposito T, Sergio C, Cibelli G, Monda M, Messina G. Osteopontin: Relation between Adipose Tissue and Bone Homeostasis. Stem Cells Int. 2017;2017:4045238. doi: 10.1155/2017/4045238. Epub 2017 Jan 17. PMID: 28194185; PMCID: PMC5282444.
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Stem Cells Int. 2017;2017:4045238. doi: 10.1155/2017/4045238. Epub 2017 Jan 17.

Osteopontin: Relation between Adipose Tissue and Bone Homeostasis.

Stem cells international

Carolina De Fusco, Antonietta Messina, Vincenzo Monda, Emanuela Viggiano, Fiorenzo Moscatelli, Anna Valenzano, Teresa Esposito, Chieffi Sergio, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina

Affiliations

  1. Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy.
  2. Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy; Department of Medicine, University of Padua, Padua, Italy.
  3. Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  4. Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

PMID: 28194185 PMCID: PMC5282444 DOI: 10.1155/2017/4045238

Abstract

Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.

Conflict of interest statement

The authors declare that they have no competing interests.

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