Display options
Cite
Bivalacqua TJ, Champion HC, Hyman AL, et al. Analysis of responses to angiotensin II in the mouse. J Renin Angiotensin Aldosterone Syst. 2001;2(1):S48-S53doi: 10.1177/14703203010020010801.
Bivalacqua, T. J., Champion, H. C., Hyman, A. L., McNamara, D. B., & Kadowitz, P. J. (2001). Analysis of responses to angiotensin II in the mouse. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2(1), S48-S53. https://doi.org/10.1177/14703203010020010801
Bivalacqua, Trinity J, et al. "Analysis of responses to angiotensin II in the mouse." Journal of the renin-angiotensin-aldosterone system : JRAAS vol. 2,1 (2001): S48-S53. doi: https://doi.org/10.1177/14703203010020010801
Bivalacqua TJ, Champion HC, Hyman AL, McNamara DB, Kadowitz PJ. Analysis of responses to angiotensin II in the mouse. J Renin Angiotensin Aldosterone Syst. 2001 Mar;2(1):S48-S53. doi: 10.1177/14703203010020010801. PMID: 28095236.
Copy Download .nbib Format: NLM
Share it on

J Renin Angiotensin Aldosterone Syst. 2001 Mar;2(1):S48-S53. doi: 10.1177/14703203010020010801.

Analysis of responses to angiotensin II in the mouse.

Journal of the renin-angiotensin-aldosterone system : JRAAS

Trinity J Bivalacqua, Hunter C Champion, Albert L Hyman, Dennis B McNamara, Philip J Kadowitz

Affiliations

  1. Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  2. Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA, [email protected].

PMID: 28095236 DOI: 10.1177/14703203010020010801

Abstract

Responses to angiotensin II (Ang II) were investigated in anaesthetised CD1 mice. Injections of Ang II caused dose-related increases in systemic arterial pressure that were antagonised by candesartan. Responses to Ang II were not altered by PD 123319. At the lowest dose studied (20 µg/kg i.v.), the inhibitory effects of candesartan were competitive, whereas at the highest dose (100 µg/kg i.v.), the dose-response curve for Ang II was shifted to the right in a non-parallel manner. The inhibitory effects of candesartan were selective and were similar in animals pretreated with enalaprilat to reduce endogenous Ang II production. Pressor responses to Ang II were not altered by propranolol, phentolamine or atropine, but were enhanced by hexamethonium. Increases in total peripheral resistance were inhibited by the AT1-receptor antagonist (ARB) but were not altered by AT2-receptor, alpha- or beta-receptor antagonists. These results suggest that pressor responses to Ang II are mediated by AT 1-receptors, are buffered by the baroreceptors, are not modulated by effects on AT2receptors, and that activation of the sympathetic nervous system plays little role in mediating rapid haemodynamic responses to the peptide in anaesthetised mice.

Keywords: angiotensin II; mouse; systemic arterial pressure

Publication Types