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Prinz P, Stengel A. Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity. J Neurogastroenterol Motil. 2017;23(2):180-196doi: 10.5056/jnm16194.
Prinz, P., & Stengel, A. (2017). Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity. Journal of neurogastroenterology and motility, 23(2), 180-196. https://doi.org/10.5056/jnm16194
Prinz, Philip, and Stengel, Andreas. "Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity." Journal of neurogastroenterology and motility vol. 23,2 (2017): 180-196. doi: https://doi.org/10.5056/jnm16194
Prinz P, Stengel A. Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity. J Neurogastroenterol Motil. 2017 Apr 30;23(2):180-196. doi: 10.5056/jnm16194. PMID: 28096522; PMCID: PMC5383113.
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J Neurogastroenterol Motil. 2017 Apr 30;23(2):180-196. doi: 10.5056/jnm16194.

Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity.

Journal of neurogastroenterology and motility

Philip Prinz, Andreas Stengel

Affiliations

  1. Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.

PMID: 28096522 PMCID: PMC5383113 DOI: 10.5056/jnm16194

Abstract

This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative-physical activity and pharmacotherapy-treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways.

Keywords: Bariatric surgery; Brain-gut axis; Deep brain stimulation; Obesity; Psychosomatic

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