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Emilda AS, Veri N, Alchalidi A. High dose of green tea infusion normalized spiral artery density in rats treated with the depot-medroxyprogesterone acetate. J Intercult Ethnopharmacol. 2016;6(1):65-67doi: 10.5455/jice.20160928012442.
Emilda, A. S., Veri, N., & Alchalidi, A. (2017). High dose of green tea infusion normalized spiral artery density in rats treated with the depot-medroxyprogesterone acetate. Journal of intercultural ethnopharmacology, 6(1), 65-67. https://doi.org/10.5455/jice.20160928012442
Emilda, A S, et al. "High dose of green tea infusion normalized spiral artery density in rats treated with the depot-medroxyprogesterone acetate." Journal of intercultural ethnopharmacology vol. 6,1 (2017): 65-67. doi: https://doi.org/10.5455/jice.20160928012442
Emilda AS, Veri N, Alchalidi A. High dose of green tea infusion normalized spiral artery density in rats treated with the depot-medroxyprogesterone acetate. J Intercult Ethnopharmacol. 2016 Oct 04;6(1):65-67. doi: 10.5455/jice.20160928012442. eCollection 2017. PMID: 28163962; PMCID: PMC5289090.
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J Intercult Ethnopharmacol. 2016 Oct 04;6(1):65-67. doi: 10.5455/jice.20160928012442. eCollection 2017.

High dose of green tea infusion normalized spiral artery density in rats treated with the depot-medroxyprogesterone acetate.

Journal of intercultural ethnopharmacology

A S Emilda, Nora Veri, Alchalidi Alchalidi

Affiliations

  1. Midwifery Study Programme of Langsa, Health Polytechnical of Aceh, Aceh, Indonesia.

PMID: 28163962 PMCID: PMC5289090 DOI: 10.5455/jice.20160928012442

Abstract

AIM: The purpose of this study was to investigate the effects of green tea (GT) on the spiral artery density and endometrial thickness in female rats treated with the depot-medroxyprogesterone acetate (DMPA).

MATERIAL AND METHODS: A total of 24 female rats were randomly divided into four groups (n = 6 each): The control group (no treatment), the DMPA-treated group, treated with DMPA and GT doses of 165 mg/kg of body weight/day, and treated with DMPA and GT doses of 330 mg/kg of body weight/day. Spiral artery density and endometrial thickness were subjected to histopathological analysis.

RESULTS: Spiral artery density decreased in the DMPA-treated group, despite the insignificant difference (

CONCLUSIONS: DMPA induced a decrease in spiral artery density, despite the insignificant differences, and these changes could be normalized by the administration of high doses of GT. Therefore, GT could be a candidate herb to prevent the adverse effects of the contraceptive DMPA.

Keywords: Contraceptive; endometrium; histology; progestin; uterus; xenobiotics

Conflict of interest statement

Conflicts of Interest: None declared.

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