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Yunusova NV, Villert AB, Spirina LV, et al. Insulin-Like Growth Factors and Their Binding Proteins in Tumors and Ascites of Ovarian Cancer Patients: Association With Response To Neoadjuvant Chemotherapy. Asian Pac J Cancer Prev. 2016;17(12):5315-5320doi: 10.22034/APJCP.2016.17.12.5315.
Yunusova, N. V., Villert, A. B., Spirina, L. V., Frolova, A. E., Kolomiets, L. A., & Kondakova, I. V. (2016). Insulin-Like Growth Factors and Their Binding Proteins in Tumors and Ascites of Ovarian Cancer Patients: Association With Response To Neoadjuvant Chemotherapy. Asian Pacific journal of cancer prevention : APJCP, 17(12), 5315-5320. https://doi.org/10.22034/APJCP.2016.17.12.5315
Yunusova, Natalia V, et al. "Insulin-Like Growth Factors and Their Binding Proteins in Tumors and Ascites of Ovarian Cancer Patients: Association With Response To Neoadjuvant Chemotherapy." Asian Pacific journal of cancer prevention : APJCP vol. 17,12 (2016): 5315-5320. doi: https://doi.org/10.22034/APJCP.2016.17.12.5315
Yunusova NV, Villert AB, Spirina LV, Frolova AE, Kolomiets LA, Kondakova IV. Insulin-Like Growth Factors and Their Binding Proteins in Tumors and Ascites of Ovarian Cancer Patients: Association With Response To Neoadjuvant Chemotherapy. Asian Pac J Cancer Prev. 2016 Dec 01;17(12):5315-5320. doi: 10.22034/APJCP.2016.17.12.5315. PMID: 28125879; PMCID: PMC5454676.
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Asian Pac J Cancer Prev. 2016 Dec 01;17(12):5315-5320. doi: 10.22034/APJCP.2016.17.12.5315.

Insulin-Like Growth Factors and Their Binding Proteins in Tumors and Ascites of Ovarian Cancer Patients: Association With Response To Neoadjuvant Chemotherapy.

Asian Pacific journal of cancer prevention : APJCP

Natalia V Yunusova, Alisa B Villert, Liudmila V Spirina, Alena E Frolova, Larisa A Kolomiets, Irina V Kondakova

Affiliations

  1. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. Email: [email protected]

PMID: 28125879 PMCID: PMC5454676 DOI: 10.22034/APJCP.2016.17.12.5315

Abstract

Purpose: Tumor cell growth and sensitivity to chemotherapy depend on many factors, among which insulin-like growth factors (IGFs) may play important roles. The aim of the present study was to evaluate the levels of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in primary tumors and ascites as predictors of response to neoadjuvant chemotherapy in ovarian cancer (OC) patients. Materials and Methods: Tumor tissue samples and ascitic fluid were obtained from 59 patients with advanced OC. The levels of IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A were determined using ELISA kits. Taking into account the data on expression of these IGF-related proteins and outcome, logistic regression was performed to identify predictors of response to neoajuvant chemotherapy. Results: Human ovarian tumors expressed IGFs, IGFBP-3, IGFBP-4 and PAPP-A and these proteins were also present in ascites fluid and associated with its volume. IGFs and IGFBPs in ascites and soluble PAPP-A might play a key role in ovarian cancer progression . However, levels of proteins of the IGF system in tumors were not significant predictors of objective clinical response (oCR). Univariate analysis showed that the level of IGF-I in ascites was the only independent predictor for oCR. Conclusion: The level of IGF-I in ascites was shown to be an independent predictor of objective clinical response to chemotherapy for OC patients treated with neoadjuvant chemotherapy and debulking surgery.

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Keywords: Insulin-like growth factors; insulin-like growth factor binding proteins; ovarian cancer; ascites

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