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Walrave L, Vinken M, Albertini G, et al. Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory. Front Cell Neurosci. 2016;10:288doi: 10.3389/fncel.2016.00288.
Walrave, L., Vinken, M., Albertini, G., De Bundel, D., Leybaert, L., & Smolders, I. J. (2016). Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory. Frontiers in cellular neuroscience, 10288. https://doi.org/10.3389/fncel.2016.00288
Walrave, Laura, et al. "Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory." Frontiers in cellular neuroscience vol. 10 (2016): 288. doi: https://doi.org/10.3389/fncel.2016.00288
Walrave L, Vinken M, Albertini G, De Bundel D, Leybaert L, Smolders IJ. Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory. Front Cell Neurosci. 2016 Dec 20;10:288. doi: 10.3389/fncel.2016.00288. eCollection 2016. PMID: 28066184; PMCID: PMC5168429.
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Front Cell Neurosci. 2016 Dec 20;10:288. doi: 10.3389/fncel.2016.00288. eCollection 2016.

Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory.

Frontiers in cellular neuroscience

Laura Walrave, Mathieu Vinken, Giulia Albertini, Dimitri De Bundel, Luc Leybaert, Ilse J Smolders

Affiliations

  1. Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel Brussels, Belgium.
  2. Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel Brussels, Belgium.
  3. Physiology Group, Department of Basic Medical Sciences, Ghent University Ghent, Belgium.

PMID: 28066184 PMCID: PMC5168429 DOI: 10.3389/fncel.2016.00288

Abstract

Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ones, for example by passive diffusion via connexin hemichannels (HCs). We here investigated whether interfering with connexin43 (Cx43) HCs influenced hippocampal spatial memory. We made use of the peptide Gap19 that blocks HCs but not gap junction channels and is specific for Cx43. To this end, we microinfused transactivator of transcription linked Gap19 (TAT-Gap19) into the brain ventricle of male NMRI mice and assessed spatial memory in a Y maze. We found that the

Keywords: TAT-Gap19; Y maze; connexin43; short-term memory; working memory

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