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Gnocchi D, Bruscalupi G. Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications. Biology (Basel). 2017;6(1)doi: 10.3390/biology6010010.
Gnocchi, D., & Bruscalupi, G. (2017). Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications. Biology, 6(1), . https://doi.org/10.3390/biology6010010
Gnocchi, Davide, and Bruscalupi, Giovannella. "Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications." Biology vol. 6,1 (2017). doi: https://doi.org/10.3390/biology6010010
Gnocchi D, Bruscalupi G. Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications. Biology (Basel). 2017 Feb 04;6(1). doi: 10.3390/biology6010010. PMID: 28165421; PMCID: PMC5372003.
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Biology (Basel). 2017 Feb 04;6(1). doi: 10.3390/biology6010010.

Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications.

Biology

Davide Gnocchi, Giovannella Bruscalupi

Affiliations

  1. Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm 14186, Sweden. [email protected].
  2. Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Rome 00185, Italy. [email protected].

PMID: 28165421 PMCID: PMC5372003 DOI: 10.3390/biology6010010

Abstract

Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation of our physiology, including hormonal and metabolic homeostasis. Here we will review the structure, organisation and molecular machinery that make our circadian clock work, and its relevance for the proper functioning of physiological processes. We will also describe the interconnections between circadian rhythms and endocrine homeostasis, as well as the underlying consequences that circadian dysregulations might have in the development of several pathologic affections. Finally, we will discuss how a better knowledge of such relationships might prove helpful in designing new therapeutic approaches for endocrine and metabolic diseases.

Keywords: central oscillator; circadian clock; hormonal homeostasis; metabolic diseases; peripheral oscillators

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