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Front Immunol. 2017 Jan 23;8:19. doi: 10.3389/fimmu.2017.00019. eCollection 2017.

Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?.

Frontiers in immunology

Jennifer A Juno, David van Bockel, Stephen J Kent, Anthony D Kelleher, John J Zaunders, C Mee Ling Munier

Affiliations

  1. Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne , Melbourne, VIC , Australia.
  2. Immunovirology and Pathogenesis Program, The Kirby Institute for Infection and Immunity in Society, University of New South Wales Australia , Sydney, NSW , Australia.
  3. Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Melbourne, VIC, Australia; Melbourne Sexual Health Centre, Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University, Melbourne, VIC, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, VIC, Australia.
  4. Immunovirology and Pathogenesis Program, The Kirby Institute for Infection and Immunity in Society, University of New South Wales Australia, Sydney, NSW, Australia; St Vincent's Hospital, Sydney, NSW, Australia.

PMID: 28167943 PMCID: PMC5253382 DOI: 10.3389/fimmu.2017.00019

Abstract

CD4 T cells with cytotoxic function were once thought to be an artifact due to long-term

Keywords: CD4; CMV; EBV; HIV; cytotoxic; granzyme; influenza; perforin

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