Display options
Cite
Yang B, Guo WH, Lan T, et al. CT-guided . Exp Ther Med. 2016;12(6):3843-3850doi: 10.3892/etm.2016.3897.
Yang, B., Guo, W. H., Lan, T., Yuan, F., Liu, G. J., Zan, R. Y., You, X., Tan, Q. Y., & Liao, Z. Y. (2016). CT-guided . Experimental and therapeutic medicine, 12(6), 3843-3850. https://doi.org/10.3892/etm.2016.3897
Yang, Biao, et al. "CT-guided ." Experimental and therapeutic medicine vol. 12,6 (2016): 3843-3850. doi: https://doi.org/10.3892/etm.2016.3897
Yang B, Guo WH, Lan T, Yuan F, Liu GJ, Zan RY, You X, Tan QY, Liao ZY. CT-guided . Exp Ther Med. 2016 Dec;12(6):3843-3850. doi: 10.3892/etm.2016.3897. Epub 2016 Nov 14. PMID: 28101168; PMCID: PMC5228165.
Copy Download .nbib Format: NLM
Share it on

Exp Ther Med. 2016 Dec;12(6):3843-3850. doi: 10.3892/etm.2016.3897. Epub 2016 Nov 14.

CT-guided .

Experimental and therapeutic medicine

Biao Yang, Wen-Hao Guo, Ting Lan, Fang Yuan, Guan-Jian Liu, Rui-Yu Zan, Xin You, Qiao-Yue Tan, Zheng-Yin Liao

Affiliations

  1. Department of Abdominal Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  2. Department of Pathology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  3. Department of Radiology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
  4. Chinese Evidence-Based Medicine Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

PMID: 28101168 PMCID: PMC5228165 DOI: 10.3892/etm.2016.3897

Abstract

Radical surgery is currently the first treatment of choice for retroperitoneal soft tissue sarcoma (RSTS). However, the prognosis of RSTS remains poor due to ineffective local control and a high incidence of metastasis after surgical resection. Brachytherapy has been shown to safely provide local radiotherapy for numerous types of cancer when used alone or in combination with surgical resection, but has not been well characterized in the management of RSTS. The aim of this study was to evaluate CT-guided 125I seed implantation for local control and pain relief in the treatment of inoperable RSTS. A total of 23 patients with RSTS were treated with 125I implantation. Pain was assessed using a visual analog scale. Other endpoints were evaluated via computed tomography scan or phone call/e-mail records. The occurrence of complications was assessed preoperatively (baseline) and during postoperatively follow-up or until patient succumbed. All patients were successfully treated with 125I implantation. A mean number of 70.87 radioactive seeds were applied in each patient. During the follow-up, two patients were unaccounted for, local recurrence occurred in three patients, five succumbed and complications were observed in sixteen. The patient's VAS score changed from 7.4 preoperatively to 7.6, 2.3, 2.0, 1.2, 1.5, 1.4 and 2.5 at 24 h, 1, 3, 6, 12, 24 and 36 months after the procedure, respectively. Good local control and significant pain relief after 125I seed implantation was observed in patients with inoperable RSTS. Thus, the present results suggest that this method could be an effective treatment option for patients with inoperable RSTS.

Keywords: 125I seed; brachytherapy; iodine radioisotopes; retroperitoneal space; soft tissue sarcoma

References

  1. Eur Urol. 2002 Apr;41(4):427-33 - PubMed
  2. Arch Surg. 1995 Oct;130(10):1104-9 - PubMed
  3. Cancer. 1990 Oct 15;66(8):1703-10 - PubMed
  4. J Clin Oncol. 2009 Jan 1;27(1):31-7 - PubMed
  5. Acta Radiol Oncol. 1986 Jan-Feb;25(1):37-9 - PubMed
  6. J Neurosurg Spine. 2012 Aug;17 (2):173-6 - PubMed
  7. Cancer. 1999 Mar 1;85(5):1077-83 - PubMed
  8. Strahlenther Onkol. 2003 Feb;179(2):118-22 - PubMed
  9. Curr Probl Surg. 1996 Oct;33(10):817-72 - PubMed
  10. Ann R Coll Surg Engl. 2011 May;93(4):275-80 - PubMed
  11. Eur J Cancer. 1996 Apr;32A(4):622-6 - PubMed
  12. Gut. 2003 May;52 Suppl 3:iii1-8 - PubMed
  13. Brachytherapy. 2013 May-Jun;12(3):179-90 - PubMed
  14. Surg Oncol Clin N Am. 1997 Oct;6(4):847-62 - PubMed
  15. Korean J Radiol. 2013 Mar-Apr;14 (2):278-82 - PubMed
  16. J Dermatol. 2004 Jan;31(1):42-6 - PubMed
  17. Tech Vasc Interv Radiol. 2011 Sep;14 (3):124-8 - PubMed
  18. Cardiovasc Intervent Radiol. 2008 Jul;31 Suppl 2:S213-6 - PubMed
  19. N Engl J Med. 2005 Aug 18;353(7):701-11 - PubMed
  20. Semin Surg Oncol. 1994 Sep-Oct;10(5):364-8 - PubMed
  21. Med Phys. 2000 Aug;27(8):1789-99 - PubMed
  22. Cancer Control. 2011 Jul;18(3):177-87 - PubMed
  23. Ann Surg Oncol. 2006 Feb;13(2):245-52 - PubMed
  24. Ann Surg. 1998 Sep;228(3):355-65 - PubMed
  25. Semin Oncol. 2011 Oct;38 Suppl 3:S19-29 - PubMed
  26. Eur J Cancer. 2009 Jan;45(2):228-47 - PubMed
  27. Lancet. 1997 Dec 6;350(9092):1647-54 - PubMed
  28. J Clin Oncol. 1997 Aug;15(8):2832-9 - PubMed
  29. Br J Surg. 2005 Feb;92(2):246-52 - PubMed
  30. Cardiovasc Intervent Radiol. 2007 Mar-Apr;30(2):201-6 - PubMed
  31. Br J Radiol. 1975 Dec;48(576):1034-5 - PubMed
  32. Cancer Control. 2005 Jan-Feb;12(1):36-43 - PubMed
  33. Med Phys. 1995 Feb;22(2):209-34 - PubMed
  34. Radiother Oncol. 2006 Jan;78(1):47-52 - PubMed
  35. Prostate. 2005 Nov 1;65(3):260-7 - PubMed
  36. Ann Surg. 1990 Jul;212(1):51-9 - PubMed

Publication Types