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Kenchappa R, Bodke YD, Telkar S, et al. Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation. J Chem Biol. 2016;10(1):11-23doi: 10.1007/s12154-016-0160-x.
Kenchappa, R., Bodke, Y. D., Telkar, S., & Aruna Sindhe, M. (2017). Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation. Journal of chemical biology, 10(1), 11-23. https://doi.org/10.1007/s12154-016-0160-x
Kenchappa, R, et al. "Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation." Journal of chemical biology vol. 10,1 (2017): 11-23. doi: https://doi.org/10.1007/s12154-016-0160-x
Kenchappa R, Bodke YD, Telkar S, Aruna Sindhe M. Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation. J Chem Biol. 2016 Sep 08;10(1):11-23. doi: 10.1007/s12154-016-0160-x. eCollection 2017 Jan. PMID: 28101251; PMCID: PMC5218922.
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J Chem Biol. 2016 Sep 08;10(1):11-23. doi: 10.1007/s12154-016-0160-x. eCollection 2017 Jan.

Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation.

Journal of chemical biology

R Kenchappa, Yadav D Bodke, Sandeep Telkar, M Aruna Sindhe

Affiliations

  1. Department of P.G. Studies and Research in Industrial Chemistry, Jnana Sahyadri, Kuvempu University, Shankaraghatta, Shivamogga, Karnataka 577451 India.
  2. Department of P.G. Studies and Research in Biotechnology and Bioinformatics, Jnana sahyadri, Kuvempu University, Shankaraghatta, Karnataka, 577 451 India.

PMID: 28101251 PMCID: PMC5218922 DOI: 10.1007/s12154-016-0160-x

Abstract

A novel series of thiazolo[3,2-a]benzimidazole derivatives containing benzofuran nucleus (5a-l) have been synthesized. The key intermediate, substituted benzimidazol-sulfanyl benzofuran ethanone (3a-d) was prepared by refluxing the mixture of substituted 2-acetyl benzofuran and substituted 2-mercaptobenzimidazole in acetic acid. The cyclisation of compounds (3a-d) using polyphosphoric acid furnished the corresponding 6-substituted benzofuran thiazolo[3,2-

Keywords: Anthelmintic activity; Antifungal; Benzimidazole; Benzofuran; Mannich base; Molecular docking; β-Tubulin

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