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Saga Y, Araki T, Araya H, et al. Identification of Serratane Synthase Gene from the Fern Lycopodium clavatum. Org Lett. 2017;19(3):496-499doi: 10.1021/acs.orglett.6b03659.
Saga, Y., Araki, T., Araya, H., Saito, K., Yamazaki, M., Suzuki, H., & Kushiro, T. (2017). Identification of Serratane Synthase Gene from the Fern Lycopodium clavatum. Organic letters, 19(3), 496-499. https://doi.org/10.1021/acs.orglett.6b03659
Saga, Yusuke, et al. "Identification of Serratane Synthase Gene from the Fern Lycopodium clavatum." Organic letters vol. 19,3 (2017): 496-499. doi: https://doi.org/10.1021/acs.orglett.6b03659
Saga Y, Araki T, Araya H, Saito K, Yamazaki M, Suzuki H, Kushiro T. Identification of Serratane Synthase Gene from the Fern Lycopodium clavatum. Org Lett. 2017 Feb 03;19(3):496-499. doi: 10.1021/acs.orglett.6b03659. Epub 2017 Jan 19. PMID: 28102682.
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Org Lett. 2017 Feb 03;19(3):496-499. doi: 10.1021/acs.orglett.6b03659. Epub 2017 Jan 19.

Identification of Serratane Synthase Gene from the Fern Lycopodium clavatum.

Organic letters

Yusuke Saga, Takeshi Araki, Hiroshi Araya, Kazuki Saito, Mami Yamazaki, Hideyuki Suzuki, Tetsuo Kushiro

Affiliations

  1. Graduate School of Agriculture, Meiji University , 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
  2. Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Chuo-ku, Chiba 260-8675, Japan.
  3. Kazusa DNA Research Institute , 2-6-7 Kazusa-kamatari, Kisarazu, Chiba 292-0818, Japan.

PMID: 28102682 DOI: 10.1021/acs.orglett.6b03659

Abstract

Ferns are known to produce onoceroids including onoceranes and serratanes having unusual structures among triterpenes. From the fern Lycopodium clavatum, a novel onoceroid synthase gene was cloned that showed high sequence identity with a previously identified α-onocerin synthase. Functional analysis by coexpression with pre-α-onocerin synthase in yeast led to the production of tohogenol and serratenediol. The result suggested that serratanes are directly biosynthesized from pre-α-onocerin and not from α-onocerin as previously assumed.

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