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Luo Q, Beaver JM, Liu Y, et al. Dynamics of p53: A Master Decider of Cell Fate. Genes (Basel). 2017;8(2)doi: 10.3390/genes8020066.
Luo, Q., Beaver, J. M., Liu, Y., & Zhang, Z. (2017). Dynamics of p53: A Master Decider of Cell Fate. Genes, 8(2), . https://doi.org/10.3390/genes8020066
Luo, Qingyin, et al. "Dynamics of p53: A Master Decider of Cell Fate." Genes vol. 8,2 (2017). doi: https://doi.org/10.3390/genes8020066
Luo Q, Beaver JM, Liu Y, Zhang Z. Dynamics of p53: A Master Decider of Cell Fate. Genes (Basel). 2017 Feb 09;8(2). doi: 10.3390/genes8020066. PMID: 28208785; PMCID: PMC5333055.
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Genes (Basel). 2017 Feb 09;8(2). doi: 10.3390/genes8020066.

Dynamics of p53: A Master Decider of Cell Fate.

Genes

Qingyin Luo, Jill M Beaver, Yuan Liu, Zunzhen Zhang

Affiliations

  1. Department of Environmental Health and Occupational Medicine, Sichuan University West China School of Public Health, Chengdu 610041, China. [email protected].
  2. College of Food Science, Sichuan Agricultural University, Yaan 625014, China. [email protected].
  3. Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA. [email protected].
  4. Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA. [email protected].
  5. Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA. [email protected].
  6. Biomolecular Sciences Institute, School of Integrated Sciences and Humanity, Florida International University, Miami, FL 33199, USA. [email protected].
  7. Department of Environmental Health and Occupational Medicine, Sichuan University West China School of Public Health, Chengdu 610041, China. [email protected].

PMID: 28208785 PMCID: PMC5333055 DOI: 10.3390/genes8020066

Abstract

Cellular stress-induced temporal alterations-i.e., dynamics-are typically exemplified  by the dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially  identified as the variations of p53 protein levels. However, a growing number of studies have  shown that p53 dynamics are also manifested in variations in the activity, spatial location, and  posttranslational modifications of p53 proteins, as well as the interplay among all p53 dynamical  features. These are essential in determining a specific outcome of cell fate. In this review, we  discuss the importance of the multifaceted features of p53 dynamics and their roles in the cell fate  decision process, as well as their potential applications in p53-based cancer therapy. The review  provides new insights into p53 signaling pathways and their potentials in the development of new  strategies in p53-based cancer therapy.

Keywords: p53 dynamics;  cell fate decision;  cell signaling network

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