Display options
Share it on

ACS Med Chem Lett. 2016 Nov 28;8(1):90-95. doi: 10.1021/acsmedchemlett.6b00392. eCollection 2017 Jan 12.

[No title available]

ACS medicinal chemistry letters

Teng Ai, Rose Willett, Jessica Williams, Rui Ding, Daniel J Wilson, Jiashu Xie, Do-Hyung Kim, Rosa Puertollano, Liqiang Chen

Affiliations

  1. Center for Drug Design, Academic Health Center, University of Minnesota , Minneapolis, Minnesota 55455, United States.
  2. Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.
  3. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota , Minneapolis, Minnesota 55455, United States.

PMID: 28105281 PMCID: PMC5238460 DOI: 10.1021/acsmedchemlett.6b00392

Abstract

Guided by antiproliferative activity in MIA PaCa-2 cells, we have performed preliminary structure-activity relationship studies on

Keywords: Autophagy; anticancer agents; autophagy modulator; mTOR; pancreatic cancer

References

  1. Cancer Sci. 2008 Sep;99(9):1813-9 - PubMed
  2. Annu Rev Genet. 2009;43:67-93 - PubMed
  3. ACS Med Chem Lett. 2015 Jan 08;6(2):134-9 - PubMed
  4. Cell Death Dis. 2013 Oct 10;4:e838 - PubMed
  5. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):182-7 - PubMed
  6. Nat Cell Biol. 2014 Nov;16(11):1069-79 - PubMed
  7. J Med Chem. 2015 Aug 13;58(15):5900-15 - PubMed
  8. Nature. 2013 Dec 12;504(7479):296-300 - PubMed
  9. Genes Dev. 2011 Apr 1;25(7):717-29 - PubMed
  10. Pharmacol Res. 2016 Mar;105:164-75 - PubMed
  11. Autophagy. 2016;12 (1):1-222 - PubMed
  12. J Med Chem. 2015 Apr 9;58(7):3025-35 - PubMed
  13. Semin Cancer Biol. 2015 Dec;35:11-9 - PubMed
  14. Cancer Discov. 2014 Aug;4(8):905-13 - PubMed
  15. EMBO J. 2015 Apr 1;34(7):856-80 - PubMed
  16. ACS Med Chem Lett. 2016 Jun 25;7(8):802-6 - PubMed
  17. Autophagy. 2012 Feb 1;8(2):200-12 - PubMed
  18. Mol Cell. 2015 Jul 16;59(2):285-97 - PubMed
  19. J Med Chem. 2015 Jan 8;58(1):376-400 - PubMed
  20. Cell. 2011 Sep 30;147(1):223-34 - PubMed
  21. ACS Med Chem Lett. 2015 Nov 13;7(1):72-6 - PubMed
  22. Bioorg Med Chem. 2015 Sep 1;23 (17 ):5483-8 - PubMed
  23. Proc Natl Acad Sci U S A. 2012 May 22;109 (21):8253-8 - PubMed
  24. ACS Chem Biol. 2015 Jan 16;10 (1):257-61 - PubMed

Publication Types

Grant support