Display options
Cite
Chang X, Chin HL, Quek SC, et al. The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (. Thromb J. 2017;15:1doi: 10.1186/s12959-016-0124-y.
Chang, X., Chin, H. L., Quek, S. C., Goh, D. Y., Dorajoo, R., Friedlander, Y., & Heng, C. K. (2017). The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (. Thrombosis journal, 151. https://doi.org/10.1186/s12959-016-0124-y
Chang, Xuling, et al. "The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (." Thrombosis journal vol. 15 (2017): 1. doi: https://doi.org/10.1186/s12959-016-0124-y
Chang X, Chin HL, Quek SC, Goh DY, Dorajoo R, Friedlander Y, Heng CK. The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (. Thromb J. 2017 Jan 07;15:1. doi: 10.1186/s12959-016-0124-y. eCollection 2017. PMID: 28074087; PMCID: PMC5219704.
Copy Download .nbib Format: NLM
Share it on

Thromb J. 2017 Jan 07;15:1. doi: 10.1186/s12959-016-0124-y. eCollection 2017.

The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (.

Thrombosis journal

Xuling Chang, Hui-Lin Chin, Swee-Chye Quek, Daniel Y T Goh, Rajkumar Dorajoo, Yechiel Friedlander, Chew-Kiat Heng

Affiliations

  1. Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
  2. Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
  3. School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

PMID: 28074087 PMCID: PMC5219704 DOI: 10.1186/s12959-016-0124-y

Abstract

BACKGROUND: Genome-wide association study (GWAS) has reported that rs6903956 within the first intron of androgen-dependent tissue factor pathway inhibitor (TFPI) regulating protein (

METHODS: We conducted the analysis in both Chinese adult (

RESULTS: No significant association was observed between rs6903956 and plasma FVIIc nor fibrinogen levels with adjustment for age, gender, body mass index (BMI) and cigarette smoking in adults (P for FVIIc = 0.464; P for fibrinogen = 0.349). The SNP was also not associated with these two coagulation factors in the neonates (P for FVIIc = 0.579; P for fibrinogen = 0.359) after adjusting for gestational age, gender and birth weight.

CONCLUSIONS: SNP rs6903956 on

Keywords: Androgen-dependent tissue factor pathway inhibitor regulating protein; Coagulation factors; Coronary artery disease; Genetic variant

References

  1. Nat Genet. 2011 Mar 06;43(4):345-9 - PubMed
  2. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6687-91 - PubMed
  3. PLoS One. 2012;7(8):e43732 - PubMed
  4. J Med Genet. 2001 Sep;38(9):E31 - PubMed
  5. Vasc Health Risk Manag. 2008;4(1):11-21 - PubMed
  6. Br J Haematol. 1995 Dec;91(4):777-82 - PubMed
  7. Lancet. 2015 Jan 10;385(9963):117-71 - PubMed
  8. Nat Genet. 2011 Mar 06;43(4):333-8 - PubMed
  9. Thromb J. 2012 Aug 10;10(1):12 - PubMed
  10. Arterioscler Thromb. 1994 Jan;14(1):54-9 - PubMed
  11. Pediatr Res. 1996 Nov;40(5):718-22 - PubMed
  12. Curr Cardiol Rep. 2012 Aug;14(4):450-6 - PubMed
  13. J Atheroscler Thromb. 2014;21(7):680-90 - PubMed
  14. N Engl J Med. 1992 Mar 19;326(12):800-6 - PubMed
  15. Clin Cardiol. 1992 May;15(5):358-64 - PubMed
  16. MMWR Morb Mortal Wkly Rep. 2011 Oct 14;60(40):1377-81 - PubMed
  17. Acta Haematol. 1957 Apr;17(4):237-46 - PubMed
  18. Ann Hum Genet. 2006 Nov;70(Pt 6):951-7 - PubMed
  19. Lancet. 2012 Dec 15;380(9859):2095-128 - PubMed
  20. Circulation. 2004 Jun 15;109(23):2911-6 - PubMed
  21. Int J Inflam. 2012;2012:860301 - PubMed
  22. Arterioscler Thromb Vasc Biol. 2002 Feb 1;22(2):353-8 - PubMed
  23. Clin Biochem. 2013 Jun;46(9):755-9 - PubMed
  24. Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1687-93 - PubMed
  25. Arterioscler Thromb. 1994 Dec;14(12):1923-7 - PubMed
  26. N Engl J Med. 2005 Apr 21;352(16):1685-95 - PubMed
  27. Circulation. 2004 Jun 15;109 (23 Suppl 1):III27-32 - PubMed
  28. Blood. 2011 Oct 20;118(16):4463-71 - PubMed
  29. Thromb Haemost. 1995 Jul;74(1):90-3 - PubMed
  30. Hellenic J Cardiol. 2010 Jan-Feb;51(1):1-9 - PubMed
  31. Lancet. 1993 Oct 30;342(8879):1076-9 - PubMed
  32. Arch Mal Coeur Vaiss. 2005 Jun;98(6):667-71 - PubMed

Publication Types