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Sawai T, Imano H, Muraki I, et al. Changes in ischaemic ECG abnormalities and subsequent risk of cardiovascular disease. Heart Asia. 2017;9(1):36-43doi: 10.1136/heartasia-2016-010846.
Sawai, T., Imano, H., Muraki, I., Hayama-Terada, M., Shimizu, Y., Cui, R., Kitamura, A., Kiyama, M., Okada, T., Ohira, T., Yamagishi, K., Umesawa, M., Sankai, T., & Iso, H. (2017). Changes in ischaemic ECG abnormalities and subsequent risk of cardiovascular disease. Heart Asia, 9(1), 36-43. https://doi.org/10.1136/heartasia-2016-010846
Sawai, Takeshi, et al. "Changes in ischaemic ECG abnormalities and subsequent risk of cardiovascular disease." Heart Asia vol. 9,1 (2017): 36-43. doi: https://doi.org/10.1136/heartasia-2016-010846
Sawai T, Imano H, Muraki I, Hayama-Terada M, Shimizu Y, Cui R, Kitamura A, Kiyama M, Okada T, Ohira T, Yamagishi K, Umesawa M, Sankai T, Iso H. Changes in ischaemic ECG abnormalities and subsequent risk of cardiovascular disease. Heart Asia. 2017 Jan 23;9(1):36-43. doi: 10.1136/heartasia-2016-010846. eCollection 2017. PMID: 28176973; PMCID: PMC5278342.
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Heart Asia. 2017 Jan 23;9(1):36-43. doi: 10.1136/heartasia-2016-010846. eCollection 2017.

Changes in ischaemic ECG abnormalities and subsequent risk of cardiovascular disease.

Heart Asia

Takeshi Sawai, Hironori Imano, Isao Muraki, Mina Hayama-Terada, Yuji Shimizu, Renzhe Cui, Akihiko Kitamura, Masahiko Kiyama, Takeo Okada, Tetsuya Ohira, Kazumasa Yamagishi, Mitsumasa Umesawa, Tomoko Sankai, Hiroyasu Iso

Affiliations

  1. Public Health, Department of Social Medicine , Osaka University Graduate School of Medicine , Osaka , Japan.
  2. Osaka Center for Cancer and Cardiovascular Disease Prevention , Osaka , Japan.
  3. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
  4. Department of Epidemiology , Fukushima Medical University School of Medicine , Fukushima , Japan.
  5. Department of Public Health Medicine, Faculty of Medicine , University of Tsukuba , Ibaraki , Japan.
  6. Department of Public Health, Dokkyo Medical University School of Medicine , Tochigi , Japan.
  7. Department of Community Health, Faculty of Medicine , University of Tsukuba , Ibaraki , Japan.

PMID: 28176973 PMCID: PMC5278342 DOI: 10.1136/heartasia-2016-010846

Abstract

OBJECTIVE: The prognostic importance of changes in ischaemic ECG abnormalities over time (especially ST-T abnormalities) among Asians has not been fully investigated. We examined the associations between changes in ischaemic abnormalities upon serial ECG (improvement, persistence, deterioration) and cardiovascular disease (CVD) risk.

METHODS: A prospective study cohort was conducted with 9374 men and women aged 40-69 years in four communities. Participants had multiple ECGs at study entry and during the next 10 years, and were followed up for a median period of 23.0 years. Total CVD (stroke and coronary heart disease) was ascertained under systematic surveillance. ECG abnormalities were defined by the Minnesota Code, ST depression (Code4), abnormal T wave (Code5) and categorised into nine groups (no-no, no-minor, no-major, minor-no, minor-minor, minor-major, major-no, major-minor, major-major) by comparison with the point of entrance and maximum change.

RESULTS: We documented 1196 CVD events. Compared with no-no abnormality, no-minor, minor-major and major-major in Code4, HRs (95% CI) adjusted for cardiovascular risk factors were 1.19 (1.00-1.42), 1.57 (1.15-2.12) and 1.87 (1.42-2.47). Similar results were observed in Code5.

CONCLUSIONS: Changes in ischaemic ECG abnormalities from none to minor, and minor to major, as well as persistent major abnormalities, were associated with an increased risk of CVD.

Conflict of interest statement

Conflicts of Interest: None declared.

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