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Kovalcuka L, Ilgazs A, Bandere D, et al. Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye. Open Vet J. 2017;7(1):16-22doi: 10.4314/ovj.v7i1.3.
Kovalcuka, L., Ilgazs, A., Bandere, D., & Williams, D. L. (2017). Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye. Open veterinary journal, 7(1), 16-22. https://doi.org/10.4314/ovj.v7i1.3
Kovalcuka, Liga, et al. "Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye." Open veterinary journal vol. 7,1 (2017): 16-22. doi: https://doi.org/10.4314/ovj.v7i1.3
Kovalcuka L, Ilgazs A, Bandere D, Williams DL. Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye. Open Vet J. 2017;7(1):16-22. doi: 10.4314/ovj.v7i1.3. Epub 2017 Jan 27. PMID: 28210543; PMCID: PMC5301057.
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Open Vet J. 2017;7(1):16-22. doi: 10.4314/ovj.v7i1.3. Epub 2017 Jan 27.

Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye.

Open veterinary journal

Liga Kovalcuka, Agris Ilgazs, Dace Bandere, David L Williams

Affiliations

  1. Latvia University of Agriculture, Faculty of Veterinary Medicine, Clinical Institute, K. Helma?a iela 8, Jelgava, LV-3004, Latvia.
  2. Riga Stradi?š University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Dzirciema iela 16, R?ga, LV-1007, Latvia.
  3. University of Cambridge, Department of Veterinary medicine, United Kingdom.

PMID: 28210543 PMCID: PMC5301057 DOI: 10.4314/ovj.v7i1.3

Abstract

The objective of this study was to determine the effects of topical 0.5% tropicamide, 1% atropine sulphate and 10% phenylephrine hydrochloride ophthalmic solutions on intraocular pressure (IOP) and horizontal pupil diameter (HPD) in the dog during the first hour after treatment. Forty clinically and ophthalmologically normal canine patients (between the ages of 2 and 6 years) of varying breed and sex were used in this study. Animals were randomly divided into four groups of ten and given one drop of tropicamide, atropine, phenylephrine or saline into one eye. IOP and HPD were measured in both eyes every 5 minutes for 60 minutes. Tropicamide increased IOP by 8.8±4.0 mmHg 35 minutes post-treatment compared to pre-treatment (P<0.01) only in treated eye. IOP in the contralateral eye did not increase. With atropine the maximum increase in IOP was 2.6±2.8 mmHg at 20 minutes post treatment in the treated eye (P<0.01). IOP in the contralateral eye did not increase. Phenylephrine increased IOP by 2.3±2.1 mmHg (P<0.05) 10 minutes after treatment. Also in the untreated eye IOP increased by 2.3±2.1 mmHg, 20 minutes post-treatment. Maximum HPD in eyes treated with tropicamide occurred at 55 minutes and with atropine at 60 minutes. There were no HPD changes in the contralateral, untreated eye. Topical 10% phenylephrine showed maximal pupil dilation 60 minutes after treatment, but the HPD of the - untreated eye slightly decreased at 15 minutes, but this change only reached statistical significance at 40 min post- treatment (P<0.05). Normal saline showed no influence on IOP or HPD. The drugs investigated here show a significant increase in IOP after mydriatics.

Keywords: Atropine sulphate; Horizontal pupil diameter; Intraocular pressure; Phenylephrine; Tropicamide

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