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Tadokoro S, Nonomura N, Kanahara N, et al. Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report. Clin Psychopharmacol Neurosci. 2017;15(1):79-81doi: 10.9758/cpn.2017.15.1.79.
Tadokoro, S., Nonomura, N., Kanahara, N., Hashimoto, K., & Iyo, M. (2017). Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 15(1), 79-81. https://doi.org/10.9758/cpn.2017.15.1.79
Tadokoro, Shigenori, et al. "Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report." Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology vol. 15,1 (2017): 79-81. doi: https://doi.org/10.9758/cpn.2017.15.1.79
Tadokoro S, Nonomura N, Kanahara N, Hashimoto K, Iyo M. Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report. Clin Psychopharmacol Neurosci. 2017 Feb 28;15(1):79-81. doi: 10.9758/cpn.2017.15.1.79. PMID: 28138118; PMCID: PMC5290712.
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Clin Psychopharmacol Neurosci. 2017 Feb 28;15(1):79-81. doi: 10.9758/cpn.2017.15.1.79.

Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Shigenori Tadokoro, Naho Nonomura, Nobuhisa Kanahara, Kenji Hashimoto, Masaomi Iyo

Affiliations

  1. Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
  2. Health Administration Center, Muroran Institute of Technology, Hokkaido, Japan.
  3. Department of Biomedical Ethics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
  4. Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Chiba, Japan.
  5. Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

PMID: 28138118 PMCID: PMC5290712 DOI: 10.9758/cpn.2017.15.1.79

Abstract

Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long-term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established. Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical antipsychotic, may reduce the exacerbation of recurrent psychotic episodes. We report the case of a 46-year-old female who suffered from schizophrenia with DSP. In this case, sustained treatment with a high dose of aripiprazole gradually reduced the　 severity of her recurrent psychotic episodes. In conclusion, sustained treatment with aripiprazole may reduce the exacerbation of recurrent psychotic episodes in schizophrenic patients with DSP, and may be an effective treatment of DSP.

Keywords: Antipsychotic agents; Disease exacerbation; Receptors, dopamine D2; Recurrence; Schizophrenia

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