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Dasen B, Vlajnic T, Mengus C, et al. T-cadherin in prostate cancer: relationship with cancer progression, differentiation and drug resistance. J Pathol Clin Res. 2016;3(1):44-57doi: 10.1002/cjp2.61.
Dasen, B., Vlajnic, T., Mengus, C., Ruiz, C., Bubendorf, L., Spagnoli, G., Wyler, S., Erne, P., Resink, T. J., & Philippova, M. (2017). T-cadherin in prostate cancer: relationship with cancer progression, differentiation and drug resistance. The journal of pathology. Clinical research, 3(1), 44-57. https://doi.org/10.1002/cjp2.61
Dasen, Boris, et al. "T-cadherin in prostate cancer: relationship with cancer progression, differentiation and drug resistance." The journal of pathology. Clinical research vol. 3,1 (2017): 44-57. doi: https://doi.org/10.1002/cjp2.61
Dasen B, Vlajnic T, Mengus C, Ruiz C, Bubendorf L, Spagnoli G, Wyler S, Erne P, Resink TJ, Philippova M. T-cadherin in prostate cancer: relationship with cancer progression, differentiation and drug resistance. J Pathol Clin Res. 2016 Nov 26;3(1):44-57. doi: 10.1002/cjp2.61. eCollection 2017 Jan. PMID: 28138401; PMCID: PMC5259566.
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J Pathol Clin Res. 2016 Nov 26;3(1):44-57. doi: 10.1002/cjp2.61. eCollection 2017 Jan.

T-cadherin in prostate cancer: relationship with cancer progression, differentiation and drug resistance.

The journal of pathology. Clinical research

Boris Dasen, Tatjana Vlajnic, Chantal Mengus, Christian Ruiz, Lukas Bubendorf, Giulio Spagnoli, Stephen Wyler, Paul Erne, Thérèse J Resink, Maria Philippova

Affiliations

  1. Department of Biomedicine, Laboratory for Signal Transduction University Hospital Basel Switzerland.
  2. Institute of Pathology, University Hospital Basel Switzerland.
  3. Institute of Surgical Research and Department of Biomedicine Basel University Hospital Switzerland.
  4. Urology Clinic, University Hospital Basel Switzerland.

PMID: 28138401 PMCID: PMC5259566 DOI: 10.1002/cjp2.61

Abstract

Prostate cancer represents the second leading cause of cancer-related death in men. T-cadherin (CDH13) is an atypical GPI-anchored member of the cadherin family of adhesion molecules. Its gene was reported to be downregulated in a small series of prostate tumours. T-cadherin protein expression/localisation in prostate tissue has never been investigated. The purpose of our study was to analyse CDH13 gene and protein levels in large sets of healthy and cancer prostate tissue specimens and evaluate CDH13 effects on the sensitivity of prostate cancer cells to chemotherapy. Analysis of CDH13 gene expression in the TCGA RNAseq dataset for prostate adenocarcinoma (

Keywords: T‐cadherin; basal and luminal cells; cadherins; doxorubicin; drug resistance; prostate cancer

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