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Pitchaiah G, Akula A, Chandi V. Anticancer Potential of Nutraceutical Formulations in MNU-induced Mammary Cancer in Sprague Dawley Rats. Pharmacogn Mag. 2017;13(49):46-50doi: 10.4103/0973-1296.197652.
Pitchaiah, G., Akula, A., & Chandi, V. (2017). Anticancer Potential of Nutraceutical Formulations in MNU-induced Mammary Cancer in Sprague Dawley Rats. Pharmacognosy magazine, 13(49), 46-50. https://doi.org/10.4103/0973-1296.197652
Pitchaiah, Gummalla, et al. "Anticancer Potential of Nutraceutical Formulations in MNU-induced Mammary Cancer in Sprague Dawley Rats." Pharmacognosy magazine vol. 13,49 (2017): 46-50. doi: https://doi.org/10.4103/0973-1296.197652
Pitchaiah G, Akula A, Chandi V. Anticancer Potential of Nutraceutical Formulations in MNU-induced Mammary Cancer in Sprague Dawley Rats. Pharmacogn Mag. 2017 Jan-Mar;13(49):46-50. doi: 10.4103/0973-1296.197652. PMID: 28216882; PMCID: PMC5307913.
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Pharmacogn Mag. 2017 Jan-Mar;13(49):46-50. doi: 10.4103/0973-1296.197652.

Anticancer Potential of Nutraceutical Formulations in MNU-induced Mammary Cancer in Sprague Dawley Rats.

Pharmacognosy magazine

Gummalla Pitchaiah, Annapurna Akula, Vishala Chandi

Affiliations

  1. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India; Department of Pharmacology, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India.
  2. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

PMID: 28216882 PMCID: PMC5307913 DOI: 10.4103/0973-1296.197652

Abstract

BACKGROUND: Nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health.

OBJECTIVE: To develop different nutraceutical formulations and to assess the anticancer potential of nutraceutical formulations in N-methyl-N-nitrosourea (MNU)-induced mammary cancer in Sprague Dawley rats.

MATERIALS AND METHODS: Different nutraceutical formulations were prepared using fine powders of amla, apple, garlic, onion, papaya, turmeric, and wheat grass with and without cow urine distillate. Total phenolic content, acute oral toxicity, and microbial load of nutraceutical formulations were assessed. The anticancer potential of nutraceutical formulations was evaluated against MNU-induced mammary cancer in female Sprague Dawley rats.

RESULTS: Improvement in total phenolic content was significant (

CONCLUSION: Combination of whole food-based nutraceuticals acted synergistically in the prevention of mammary cancer. Further, the process of fortification is novel and enhanced the anticancer potential of nutraceutical formulations.

SUMMARY: Nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health. In this study, different nutraceutical formulations using fine powders of amla, apple, garlic, onion, papaya, turmeric, and wheat grass with and without cow urine distillate. Total phenolic content, acute oral toxicity, and microbial load of nutraceutical formulations were assessed. The anticancer potential of nutraceutical formulations was evaluated against MNU-induced mammary cancer in female Sprague Dawley rats. Improvement in total phenolic content was observed after self-fortification process. Toxicity studies showed that the nutraceutical formulations were safe to use in animals. Microbial load was within the limits. Longer tumor-free days, lower tumor incidence, lower tumor multiplicity and tumor burden were observed for nutraceutical formulation-treated groups. This suggests that combination of whole food-based nutraceuticals acted synergistically in the prevention of mammary cancer. Further, the process of fortification enhanced the anticancer potential of nutraceutical formulations.

Keywords: Cow urine distillate; Fortification; Mammary Cancer; Nutraceuticals

Conflict of interest statement

There are no conflicts of interest.

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