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Zhang J, Dierckx R, Mohee K, et al. Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis. ESC Heart Fail. 2016;4(1):40-45doi: 10.1002/ehf2.12112.
Zhang, J., Dierckx, R., Mohee, K., Clark, A. L., & Cleland, J. G. (2017). Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis. ESC heart failure, 4(1), 40-45. https://doi.org/10.1002/ehf2.12112
Zhang, Jufen, et al. "Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis." ESC heart failure vol. 4,1 (2017): 40-45. doi: https://doi.org/10.1002/ehf2.12112
Zhang J, Dierckx R, Mohee K, Clark AL, Cleland JG. Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis. ESC Heart Fail. 2017 Feb;4(1):40-45. doi: 10.1002/ehf2.12112. Epub 2016 Sep 20. PMID: 28217311; PMCID: PMC5292634.
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ESC Heart Fail. 2017 Feb;4(1):40-45. doi: 10.1002/ehf2.12112. Epub 2016 Sep 20.

Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis.

ESC heart failure

Jufen Zhang, Riet Dierckx, Kevin Mohee, Andrew L Clark, John G Cleland

Affiliations

  1. Academic Cardiology, Castle Hill Hospital, Hull York Medical School, University of Hull Kingston upon Hull UK.
  2. Department of Cardiology, Cardiovascular Center, OLV Hospital Aalst Belgium.
  3. The National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College London UK.

PMID: 28217311 PMCID: PMC5292634 DOI: 10.1002/ehf2.12112

Abstract

BACKGROUND: Previous studies have shown that xanthine oxidase inhibitors (XOI) might improve outcome for patients with cardiovascular disease. However, more evidence is required.

METHODS AND RESULTS: We published a meta-analysis of trials conducted before 2014 examining the effects of XOI on mortality in patients with cardiovascular disease. At least two further trials (

CONCLUSIONS: This updated meta-analysis does not suggest that XOI exert a large reduction in mortality but also cannot exclude the possibility of substantial harm or benefit.

Keywords: Cardiovascular disease; Meta‐analysis; Mortality; Systematic review; Xanthine oxidase inhibition

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