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Nunes JM, Santareno S, Guerreiro L, et al. Lyell's Syndrome and Antimalarials: A Case Report and Clinical Review. J Glob Infect Dis. 2017;9(1):23-30doi: 10.4103/0974-777X.199994.
Nunes, J. M., Santareno, S., Guerreiro, L., & Margalho, A. F. (2017). Lyell's Syndrome and Antimalarials: A Case Report and Clinical Review. Journal of global infectious diseases, 9(1), 23-30. https://doi.org/10.4103/0974-777X.199994
Nunes, Joana Miranda, et al. "Lyell's Syndrome and Antimalarials: A Case Report and Clinical Review." Journal of global infectious diseases vol. 9,1 (2017): 23-30. doi: https://doi.org/10.4103/0974-777X.199994
Nunes JM, Santareno S, Guerreiro L, Margalho AF. Lyell's Syndrome and Antimalarials: A Case Report and Clinical Review. J Glob Infect Dis. 2017 Jan-Mar;9(1):23-30. doi: 10.4103/0974-777X.199994. PMID: 28250622; PMCID: PMC5330040.
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J Glob Infect Dis. 2017 Jan-Mar;9(1):23-30. doi: 10.4103/0974-777X.199994.

Lyell's Syndrome and Antimalarials: A Case Report and Clinical Review.

Journal of global infectious diseases

Joana Miranda Nunes, Sofia Santareno, Lina Guerreiro, Ana Filipa Margalho

Affiliations

  1. Department of Anesthesiology, Funchal Central Hospital, Madeira, Portugal.
  2. Department of Plastic Surgery and Burn Unit, North Lisbon Hospital Centre, Lisboa University Medical School, Lisboa, Portugal.
  3. Department of Anesthesiology, Pain and Emergency Medicine, North Lisbon Hospital Centre, Lisboa University Medical School, Lisboa, Portugal.
  4. Department of Plastic, Reconstructive and Aesthetic Surgery, Oncology Portuguese Institute Francisco Gentil, Lisboa, Portugal.

PMID: 28250622 PMCID: PMC5330040 DOI: 10.4103/0974-777X.199994

Abstract

Toxic epidermal necrolysis (TEN) or Lyell's syndrome is a rare, however, life-threatening mucocutaneous disorder with an epidermal detachment of a total body surface area (TBSA) of >30%. It is triggered by an idiosyncratic immune-allergic reaction to a drug, with many possible drugs implicated. Treatment success relies on early diagnosis and withdrawal of suspected/causative drug(s) and supportive care. Clinical evidence for specific therapies is still sparse. It is described a case of Lyell syndrome by sulfonamides for chemoprophylaxis of malaria. The patient presented with an extensive, rapidly evolving skin detachment, which progressed, despite supportive therapy, involving about 80% of TBSA. This led us to initiate a course of immunoglobulin with good clinical response. The aim of this work is to provide a discussion of the case and simultaneously make a practical literature review of TEN.

Keywords: Immunoglobulin; Lyell syndrome; malaria; sulfonamides; toxic epidermal necrolysis

Conflict of interest statement

There are no conflicts of interest.

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