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Lim K, Sata Y, Jackson KL, et al. Acute Effect of Central Administration of Urotensin II on Baroreflex and Blood Pressure in Conscious Normotensive Rabbits. Front Physiol. 2017;8:110doi: 10.3389/fphys.2017.00110.
Lim, K., Sata, Y., Jackson, K. L., Burke, S. L., & Head, G. A. (2017). Acute Effect of Central Administration of Urotensin II on Baroreflex and Blood Pressure in Conscious Normotensive Rabbits. Frontiers in physiology, 8110. https://doi.org/10.3389/fphys.2017.00110
Lim, Kyungjoon, et al. "Acute Effect of Central Administration of Urotensin II on Baroreflex and Blood Pressure in Conscious Normotensive Rabbits." Frontiers in physiology vol. 8 (2017): 110. doi: https://doi.org/10.3389/fphys.2017.00110
Lim K, Sata Y, Jackson KL, Burke SL, Head GA. Acute Effect of Central Administration of Urotensin II on Baroreflex and Blood Pressure in Conscious Normotensive Rabbits. Front Physiol. 2017 Feb 23;8:110. doi: 10.3389/fphys.2017.00110. eCollection 2017. PMID: 28280470; PMCID: PMC5322237.
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Front Physiol. 2017 Feb 23;8:110. doi: 10.3389/fphys.2017.00110. eCollection 2017.

Acute Effect of Central Administration of Urotensin II on Baroreflex and Blood Pressure in Conscious Normotensive Rabbits.

Frontiers in physiology

Kyungjoon Lim, Yusuke Sata, Kristy L Jackson, Sandra L Burke, Geoffrey A Head

Affiliations

  1. Department of Neuropharmacology, Baker IDI Heart and Diabetes Research InstituteMelbourne, VIC, Australia; Department of Physiology, Monash UniversityClayton, VIC, Australia.
  2. Department of Neuropharmacology, Baker IDI Heart and Diabetes Research InstituteMelbourne, VIC, Australia; Faculty of Medicine, Nursing and Health Science, Monash UniversityClayton, VIC, Australia.
  3. Department of Neuropharmacology, Baker IDI Heart and Diabetes Research Institute Melbourne, VIC, Australia.
  4. Department of Neuropharmacology, Baker IDI Heart and Diabetes Research InstituteMelbourne, VIC, Australia; Department of Pharmacology, Monash UniversityClayton, VIC, Australia.

PMID: 28280470 PMCID: PMC5322237 DOI: 10.3389/fphys.2017.00110

Abstract

In the present study, we examined the effects of central administration of Urotensin II on blood pressure, heart rate, and baroreceptor heart rate reflexes in conscious normotensive rabbits. Preliminary operations were undertaken to implant a balloon cuff on the inferior vena cava for baroreflex assessments and to implant cannula into the lateral and fourth ventricle. After 2 weeks of recovery cumulative dose response curves to Urotensin II (10, 100 ng, 1, 10, and 100 μg) given into the ventricles, or Ringer's solution as a vehicle were performed on separate days. Injections were given each hour and baroreflex assessments were made 30 min after each administration. Analysis of the dose response curves to Urotensin II compared to vehicle administered into the lateral or fourth ventricle, indicated little change to blood pressure or heart rate. Analysis of the time course to the highest dose over a 30 min period revealed a small (-5 mmHg) depressor response maximal at 10 min when injected into the fourth ventricle but no effect when injected into the lateral ventricle. Baroreflex assessments made at each dose showed that there was no change in baroreflex sensitivity but that an increase in the upper plateau was observed when Urotensin was injected into the lateral ventricle and a tendency for a reduced lower heart rate plateau was observed after fourth ventricle administration. Clonidine administration in the fourth ventricle decreased blood pressure and heart rate, thus confirming catheter patency. In conclusion, our findings suggest that Urotensin II in the forebrain and brainstem may play a role in modulating cardiac sympathetic and vagal baroreflexes but only during large acute changes in blood pressure.

Keywords: Urotensin II (SD1293); baroreflex; blood pressure; central effect; conscious rabbit

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