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Karagueuzian HS, Pezhouman A, Angelini M, et al. Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. Front Pharmacol. 2017;8:36doi: 10.3389/fphar.2017.00036.
Karagueuzian, H. S., Pezhouman, A., Angelini, M., & Olcese, R. (2017). Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. Frontiers in pharmacology, 836. https://doi.org/10.3389/fphar.2017.00036
Karagueuzian, Hrayr S, et al. "Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets." Frontiers in pharmacology vol. 8 (2017): 36. doi: https://doi.org/10.3389/fphar.2017.00036
Karagueuzian HS, Pezhouman A, Angelini M, Olcese R. Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. Front Pharmacol. 2017 Feb 06;8:36. doi: 10.3389/fphar.2017.00036. eCollection 2017. PMID: 28220073; PMCID: PMC5292429.
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Front Pharmacol. 2017 Feb 06;8:36. doi: 10.3389/fphar.2017.00036. eCollection 2017.

Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets.

Frontiers in pharmacology

Hrayr S Karagueuzian, Arash Pezhouman, Marina Angelini, Riccardo Olcese

Affiliations

  1. Translational Arrhythmia Section, David Geffen School of Medicine, University of California, Los AngelesLos Angeles, CA, USA; Cardiovascular Research Laboratory, Departments of Medicine (Cardiology), David Geffen School of Medicine, University of California, Los AngelesLos Angeles, CA, USA.
  2. Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
  3. Cardiovascular Research Laboratory, Departments of Medicine (Cardiology), David Geffen School of Medicine, University of California, Los AngelesLos Angeles, CA, USA; Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los AngelesLos Angeles, CA, USA; Department of Physiology, David Geffen School of Medicine, University of California, Los AngelesLos Angeles, CA, USA.

PMID: 28220073 PMCID: PMC5292429 DOI: 10.3389/fphar.2017.00036

Abstract

While recent advances clarified the molecular and cellular modes of action of antiarrhythmic drugs (AADs), their link to suppression of dynamical arrhythmia mechanisms remains only partially understood. The current classifications of AADs (Classes I, III, and IV) rely on blocking peak Na, K and L-type calcium currents (I

Keywords: GS-458-967; antiarrhythmic drugs; early afterdepolarization; late Ca current; late Na current; roscovitine; triggered activity; ventricular fibrillation

References

  1. J Am Coll Cardiol. 1996 Oct;28(4):813-9 - PubMed
  2. Cell. 2000 May 12;101(4):365-76 - PubMed
  3. Physiol Rev. 2005 Oct;85(4):1271-301 - PubMed
  4. Am Heart J. 1975 May;89(5):665-73 - PubMed
  5. Br J Pharmacol. 1970 Aug;39(4):657-67 - PubMed
  6. Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H180-91 - PubMed
  7. J Physiol. 2011 Dec 15;589(Pt 24):6081-92 - PubMed
  8. Pflugers Arch Gesamte Physiol Menschen Tiere. 1967;296(4):328-36 - PubMed
  9. J Mol Cell Cardiol. 2015 May;82:136-52 - PubMed
  10. Am J Cardiovasc Dis. 2013;3(1):1-16 - PubMed
  11. Heart Rhythm. 2015 Feb;12(2):440-8 - PubMed
  12. J Pharmacol Exp Ther. 1998 May;285(2):546-52 - PubMed
  13. Circ Res. 2006 May 26;98(10):1244-53 - PubMed
  14. J Pharmacol Exp Ther. 2006 Jul;318(1):214-22 - PubMed
  15. Eur Heart J Cardiovasc Pharmacother. 2016 Sep 15;:null - PubMed
  16. J Am Coll Cardiol. 2011 Jan 18;57(3):366-75 - PubMed
  17. Circulation. 2013 Feb 5;127(5):575-84 - PubMed
  18. Circ Arrhythm Electrophysiol. 2015 Aug;8(4):769-71 - PubMed
  19. Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1915-23 - PubMed
  20. Circulation. 2006 Aug 8;114(6):536-42 - PubMed
  21. J Mol Cell Cardiol. 2010 Feb;48(2):293-301 - PubMed
  22. Am J Cardiol. 1997 Jun 19;79(12A):2-10 - PubMed
  23. Physiol Rev. 2011 Jul;91(3):889-915 - PubMed
  24. J Am Coll Cardiol. 1991 Oct;18(4):1005-14 - PubMed
  25. Circ Arrhythm Electrophysiol. 2013 Jun;6(3):614-22 - PubMed
  26. Trends Cardiovasc Med. 2015 Jul;25(5):392-7 - PubMed
  27. J Am Coll Cardiol. 2014 Jan 28;63(3):259-66 - PubMed
  28. Nature. 1995 Aug 24;376(6542):683-5 - PubMed
  29. J Gen Physiol. 2015 May;145(5):395-404 - PubMed
  30. Heart Rhythm. 2008 Jul;5(7):1019-26 - PubMed
  31. Am J Cardiol. 1995 May 15;75(15):1023-7 - PubMed
  32. J Mol Cell Cardiol. 2010 Dec;49(6):911-7 - PubMed
  33. J Clin Pharmacol. 1992 Nov;32(11):964-77 - PubMed
  34. N Engl J Med. 1991 Mar 21;324(12):781-8 - PubMed
  35. Neth Heart J. 2003 Aug;11(7-8):301-309 - PubMed
  36. J Physiol. 1997 May 1;500 ( Pt 3):631-42 - PubMed
  37. J Gen Physiol. 2015 Jun;145(6):475-9 - PubMed
  38. Circulation. 2012 May 1;125(17):2059-70 - PubMed
  39. Pacing Clin Electrophysiol. 2012 Mar;35(3):e62-4 - PubMed
  40. Circulation. 1988 Jun;77(6):1395-402 - PubMed
  41. J Physiol. 2014 Mar 15;592(6):1181-97 - PubMed
  42. J Am Coll Cardiol. 1998 Jul;32(1):187-96 - PubMed
  43. Br J Pharmacol. 1970 Aug;39(4):668-74 - PubMed
  44. Cardiologia. 1969;54(2):83-90 - PubMed
  45. JAMA. 2015 Jul 21;314(3):278-88 - PubMed
  46. Nat Commun. 2016 Jan 29;7:10370 - PubMed
  47. Arzneimittelforschung. 1968 Nov;18(11):1408-17 - PubMed
  48. Ann Biomed Eng. 2000 Jul;28(7):755-71 - PubMed
  49. Biophys J. 2015 Aug 18;109(4):838-49 - PubMed
  50. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7 - PubMed
  51. Toxicon. 2007 Feb;49(2):124-41 - PubMed
  52. Prog Biophys Mol Biol. 2008 Jan-Apr;96(1-3):421-51 - PubMed
  53. Circulation. 2015 Oct 20;132(16):1528-37 - PubMed
  54. Circulation. 1992 Dec;86(6):1872-87 - PubMed
  55. Am J Cardiol. 1985 Jul 1;56(1):185-7 - PubMed
  56. Circ Res. 2003 May 2;92(8):904-11 - PubMed
  57. Cardiol J. 2008;15(2):100-21 - PubMed
  58. Cell. 2008 May 2;133(3):462-74 - PubMed
  59. J Clin Invest. 2009 May;119(5):1230-40 - PubMed
  60. Br J Pharmacol. 2007 Oct;152(3):386-95 - PubMed
  61. Mol Pharmacol. 2000 Jan;57(1):101-7 - PubMed
  62. PLoS One. 2016 Mar 01;11(3):e0149198 - PubMed
  63. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1594-605 - PubMed
  64. J Mol Cell Cardiol. 1990 Aug;22(8):921-32 - PubMed
  65. Circ Res. 2003 May 2;92(8):912-9 - PubMed
  66. J Mol Cell Cardiol. 2014 Sep;74:115-24 - PubMed
  67. Scand J Dent Res. 1989 Jun;97(3):222-32 - PubMed
  68. Drugs Aging. 1998 Aug;13(2):159-71 - PubMed
  69. Pharmacol Ther. 2016 Oct 11;:null - PubMed
  70. J Mol Cell Cardiol. 1994 Oct;26(10):1307-20 - PubMed
  71. Circulation. 1991 Oct;84(4):1831-51 - PubMed
  72. J Pharmacol Exp Ther. 2013 Jan;344(1):23-32 - PubMed
  73. Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H767-75 - PubMed
  74. Circ Res. 1968 Feb;22(2):221-36 - PubMed
  75. Circ Res. 2015 Jun 5;116(12):1956-70 - PubMed
  76. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):2983-8 - PubMed
  77. Heart Rhythm. 2012 Jan;9(1):115-22 - PubMed
  78. Cardiovasc Res. 2001 May;50(2):251-62 - PubMed
  79. Biophys J. 2010 Sep 8;99(5):1408-15 - PubMed
  80. Handb Exp Pharmacol. 2014;221:137-68 - PubMed
  81. Heart Rhythm. 2014 Mar;11(3):492-501 - PubMed
  82. Epilepsia. 2014 Aug;55(8):1274-83 - PubMed
  83. Front Pharmacol. 2015 Aug 25;6:178 - PubMed
  84. Circ Res. 1999 Apr 30;84(8):955-63 - PubMed
  85. PLoS One. 2011;6(5):e20300 - PubMed
  86. Circulation. 1988 Apr;77(4):795-805 - PubMed
  87. J Cardiovasc Transl Res. 2013 Feb;6(1):1-9 - PubMed
  88. Science. 1990 Dec 21;250(4988):1735-8 - PubMed
  89. Heart Rhythm. 2016 Nov;13(11):2228-2236 - PubMed
  90. J Clin Invest. 1991 Sep;88(3):1014-25 - PubMed
  91. Europace. 2010 Oct;12(10):1360-420 - PubMed
  92. J Physiol. 1962 Mar;160(3):470-82 - PubMed
  93. Circ Res. 2000 Dec 8;87(12):1103-7 - PubMed
  94. Circ Res. 2012 Jun 8;110(12):1661-77 - PubMed
  95. J Pharmacol Exp Ther. 1949 Mar;95(3):312-7 - PubMed
  96. J Mol Cell Cardiol. 2014 Aug;73:112-6 - PubMed
  97. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H639-48 - PubMed
  98. Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2331-40 - PubMed
  99. J Physiol. 1984 Dec;357:127-49 - PubMed
  100. Eur J Heart Fail. 2007 Mar;9(3):219-27 - PubMed
  101. Circulation. 1991 May;83(5):1499-509 - PubMed
  102. Heart Rhythm. 2011 May;8(5):762-9 - PubMed
  103. South Med J. 1959 Jun;52(6):702-6 - PubMed
  104. Experientia. 1972 Mar 15;28(3):288-9 - PubMed
  105. Prog Cardiovasc Dis. 2008 May-Jun;50(6):439-48 - PubMed
  106. Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):348-59 - PubMed
  107. Circ Res. 2009 Jan 2;104(1):79-86 - PubMed
  108. Br J Pharmacol. 1970 Aug;39(4):675-87 - PubMed
  109. J Mol Biol. 2015 Jan 16;427(1):158-75 - PubMed
  110. Pharmacol Ther. 2011 Nov;132(2):125-45 - PubMed
  111. J Cardiovasc Pharmacol. 2010 May;55(5):428-37 - PubMed
  112. Am J Physiol. 1950 Dec;163(3):505-16 - PubMed
  113. J Physiol Pharmacol. 2010 Apr;61(2):141-51 - PubMed
  114. Nature. 2011 Mar 10;471(7337):230-4 - PubMed
  115. N Engl J Med. 1991 Dec 5;325(23):1621-9 - PubMed
  116. Cardiovasc Res. 2013 Jul 1;99(1):6-15 - PubMed
  117. Nat Rev Neurosci. 2004 Jul;5(7):553-64 - PubMed

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