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Willicombe M, Rizzello A, Goodall D, et al. Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol. World J Transplant. 2017;7(1):34-42doi: 10.5500/wjt.v7.i1.34.
Willicombe, M., Rizzello, A., Goodall, D., Papalois, V., McLean, A. G., & Taube, D. (2017). Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol. World journal of transplantation, 7(1), 34-42. https://doi.org/10.5500/wjt.v7.i1.34
Willicombe, Michelle, et al. "Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol." World journal of transplantation vol. 7,1 (2017): 34-42. doi: https://doi.org/10.5500/wjt.v7.i1.34
Willicombe M, Rizzello A, Goodall D, Papalois V, McLean AG, Taube D. Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol. World J Transplant. 2017 Feb 24;7(1):34-42. doi: 10.5500/wjt.v7.i1.34. PMID: 28280693; PMCID: PMC5324026.
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World J Transplant. 2017 Feb 24;7(1):34-42. doi: 10.5500/wjt.v7.i1.34.

Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol.

World journal of transplantation

Michelle Willicombe, Anna Rizzello, Dawn Goodall, Vassilios Papalois, Adam G McLean, David Taube

Affiliations

  1. Michelle Willicombe, Anna Rizzello, Dawn Goodall, Vassilios Papalois, Adam G McLean, David Taube, Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London W12 0HS, United Kingdom.

PMID: 28280693 PMCID: PMC5324026 DOI: 10.5500/wjt.v7.i1.34

Abstract

AIM: To analyse the risk factors and outcomes of delayed graft function (DGF) in patients receiving a steroid sparing protocol.

METHODS: Four hundred and twenty-seven recipients of deceased donor kidney transplants were studied of which 135 (31.6%) experienced DGF. All patients received monoclonal antibody induction with a tacrolimus based, steroid sparing immunosuppression protocol.

RESULTS: Five year patient survival was 87.2% and 94.9% in the DGF and primary graft function (PGF) group respectively,

CONCLUSION: Alemtuzumab induction may be of benefit in preventing early rejection episodes associated with DGF. Prospective trials are required to determine optimal immunotherapy protocols for patients at high risk of DGF.

Keywords: Alemtuzumab; Allograft failure; Cold ischaemic time; Deceased donors; Delayed graft function; Rejection; Steroid sparing

Conflict of interest statement

Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.

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