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Front Immunol. 2017 Feb 06;8:87. doi: 10.3389/fimmu.2017.00087. eCollection 2017.

[No title available]

Frontiers in immunology

John P Veluchamy, Silvia Lopez-Lastra, Jan Spanholtz, Fenna Bohme, Nina Kok, Daniëlle A M Heideman, Henk M W Verheul, James P Di Santo, Tanja D de Gruijl, Hans J van der Vliet

Affiliations

  1. Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands; Glycostem Therapeutics, Oss, Netherlands.
  2. Innate Immunity Unit, Institut Pasteur, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1223, Paris, France; Université Paris-Sud (Paris-Saclay), Paris, France.
  3. Glycostem Therapeutics , Oss , Netherlands.
  4. Department of Pathology, VU University Medical Center , Amsterdam , Netherlands.
  5. Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam , Amsterdam , Netherlands.
  6. Innate Immunity Unit, Institut Pasteur, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1223, Paris, France.

PMID: 28220124 PMCID: PMC5292674 DOI: 10.3389/fimmu.2017.00087

Abstract

Therapeutic monoclonal antibodies against the epidermal growth factor receptor (EGFR) act by inhibiting EGFR downstream signaling and by eliciting a natural killer (NK) cell-mediated antitumor response. The IgG

Keywords: A-PBNK; EGFR; RAS mutation; UCB-NK; allogeneic NK cell immunotherapy; cetuximab; metastatic colorectal cancer

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